Hata Kei, Fujiwara Koichi, Kano Manabu, Inoue Takao, Nomura Sadahiro, Imoto Hirochika, Suzuki Michiyasu
Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:283-286. doi: 10.1109/EMBC.2017.8036817.
Epilepsy is a group of diseases caused by excessive neuronal activities, and one-quarter of the patients do not become seizure-free by the existing treatments. The potential treatments include focal brain cooling, which aims to cool the region where the excessive neuronal activities begin. We are developing a focal brain cooling system. The system delivers cold saline to a cranially implanted cooling device. The outflow is cooled by a Peltier device and pumped for circulation. The Peltier device and the pump are activated only when a seizure is predicted. In this research, the length of time for cooling the brain was calculated with a computational fluid dynamics (CFD)-based model of the focal brain cooling system. As a result, it takes less than 10 minutes for the average temperature 2 mm below the cooling device to reach 25.0 °C. It is much shorter than the time from seizure prediction to seizure onset when an existing algorithm for prediction is used.
癫痫是一组由神经元活动过度引起的疾病，现有治疗方法无法使四分之一的患者停止发作。潜在的治疗方法包括局灶性脑冷却，其目的是冷却神经元活动过度开始的区域。我们正在开发一种局灶性脑冷却系统。该系统将冷盐水输送到植入颅骨的冷却装置。流出物由珀耳帖装置冷却并泵送循环。珀耳帖装置和泵仅在预测到癫痫发作时才启动。在这项研究中，使用基于计算流体动力学（CFD）的局灶性脑冷却系统模型计算了冷却大脑的时间长度。结果，冷却装置下方2毫米处的平均温度达到25.0°C所需时间不到10分钟。这比使用现有预测算法从癫痫发作预测到发作开始的时间要短得多。
