Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:917-920. doi: 10.1109/EMBC.2017.8036974.
A polymer-based implantable stimulator for wirelessly navigating pigeons was conceptually suggested and a pilot study using depth electrodes was conducted. In this study, depth electrodes based on liquid crystal polymer (LCP) with eight channels were designed and fabricated. Electrochemical impedance spectrum (EIS) assessments were performed to measure impedances of the electrodes. The average value of the measured impedances was 16.8∠15.8 ° kμ. The electrodes were then advanced to a target nucleus (formatio reticularis medialis mesencephalic, FRM) of a pigeon to prove their in vivo feasibilities. Biphasic current pulses were generated by a custom-made stimulator and delivered to the electrodes to stimulate the FRM electrically. Pulses with an amplitude level of 0.567 μA, a rate of 58.0 Hz, and a duration of 1.00 ms were applied with inter-stimulus intervals of three minutes. Turning and circling behaviors were consistently shown when the FRM was stimulated. The feasibilities of the electrodes were proved in both in vitro and in vivo tests, as a pilot study for the suggested scheme. Finally, several discussions of the assessments and extensions for a fully implantable stimulator were described.
从概念上提出了一种基于聚合物的用于无线导航鸽子的植入式刺激器，并进行了一项使用深度电极的初步研究。在本研究中，设计并制造了基于液晶聚合物（LCP）的具有八个通道的深度电极。进行了电化学阻抗谱（EIS）评估以测量电极的阻抗。测量阻抗的平均值为16.8∠15.8°kΩ。然后将电极推进到鸽子的目标核（中脑内侧网状结构，FRM）以证明其在体内的可行性。由定制刺激器产生双相电流脉冲并将其输送到电极以电刺激FRM。施加幅度水平为0.567μA、频率为58.0Hz、持续时间为1.00ms的脉冲，刺激间隔为三分钟。刺激FRM时持续出现转向和盘旋行为。作为所提出方案的初步研究，在体外和体内测试中都证明了电极的可行性。最后，描述了对完全植入式刺激器的评估和扩展的一些讨论。
