Yanamadala J, Noetscher G M, Makarov S N, Pascual-Leone A
Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:1441-1444. doi: 10.1109/EMBC.2017.8037105.
Transcranial magnetic stimulation (TMS) for treatment of depression during pregnancy is an appealing alternative to fetus-threatening drugs. However, no studies to date have been performed that evaluate the safety of TMS for a pregnant mother patient and her fetus. A full-body FEM model of a pregnant woman with about 100 tissue parts has been developed specifically for the present study. This model allows accurate computations of induced electric field in every tissue given different locations of a shape-eight coil, a biphasic pulse, common TMS pulse durations, and using different values of the TMS intensity measured in SMT (Standard Motor Threshold) units. Our simulation results estimate the maximum peak values of the electric field in the fetal area for every fetal tissue separately and for the TMS intensity of one SMT unit.
经颅磁刺激（TMS）用于治疗孕期抑郁症是一种有吸引力的替代方案，可避免使用对胎儿有威胁的药物。然而，迄今为止尚未开展任何研究来评估TMS对怀孕母亲及其胎儿的安全性。本研究专门开发了一个具有约100个组织部分的孕妇全身有限元模型。该模型能够在给定“8”字形线圈的不同位置、双相脉冲、常见TMS脉冲持续时间以及使用以SMT（标准运动阈值）单位测量的不同TMS强度值的情况下，精确计算每个组织中的感应电场。我们的模拟结果分别估算了每个胎儿组织在胎儿区域内电场的最大峰值以及一个SMT单位的TMS强度下的电场峰值。
