酪氨酸羟化酶定位于11号染色体短臂，靠近胰岛素和HRAS1基因座。

Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci.

作者信息

Xue F, Kidd J R, Pakstis A J, Castiglione C M, Mallet J, Kidd K K

机构信息

Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.

出版信息

Genomics. 1988 May;2(4):288-93. doi: 10.1016/0888-7543(88)90016-x.

DOI:10.1016/0888-7543(88)90016-x

PMID:2906039

Abstract

Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. The TH locus was typed for a BglII RFLP using a cDNA clone Ty7 in four large kindreds. Pairwise analyses and multipoint analyses were carried out to map the TH locus more precisely in the region of the linked markers: D11S12, INS, and HRAS1 on 11p. Results confirm the close linkage between TH with these previously mapped markers and support a most likely ordering which places TH on the side of INS where the centromere lies.

摘要

酪氨酸羟化酶（TH）是儿茶酚胺生物合成的限速酶，也是躁郁症的候选基因。利用一个cDNA克隆Ty7，对四个大家系中的BglII限制性片段长度多态性（RFLP）进行了TH基因座分型。进行了成对分析和多点分析，以便在11号染色体短臂上的连锁标记D11S12、胰岛素基因（INS）和哈-柔二氏肉瘤病毒癌基因1（HRAS1）区域更精确地定位TH基因座。结果证实了TH与这些先前定位的标记之间的紧密连锁，并支持一种最可能的排序，即将TH置于着丝粒所在的INS一侧。