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相似文献

1
Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11.酪氨酸羟化酶与11号染色体短臂上的其他四个标记的连锁关系。
Nucleic Acids Res. 1986 Dec 22;14(24):9927-32. doi: 10.1093/nar/14.24.9927.
2
Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci.酪氨酸羟化酶定位于11号染色体短臂，靠近胰岛素和HRAS1基因座。
Genomics. 1988 May;2(4):288-93. doi: 10.1016/0888-7543(88)90016-x.
3
Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.人类酪氨酸羟化酶基因和胰岛素基因在11号染色体上相邻。
Nucleic Acids Res. 1988 May 25;16(10):4437-46.
4
Tyrosine hydroxylase gene not linked to manic-depression in seven of eight pedigrees.在八个家系中的七个家系中，酪氨酸羟化酶基因与躁郁症不相关。
Hum Hered. 1992;42(4):259-63. doi: 10.1159/000154079.
5
Multipoint mapping studies of the beta-globin, insulin, and c-Ha-ras-1 loci on 11p.对11号染色体上β-珠蛋白、胰岛素和c-Ha-ras-1基因座的多点定位研究。
Am J Hum Genet. 1986 Oct;39(4):539-41.
6
Linkage analysis of juvenile parkinsonism to tyrosine hydroxylase gene locus on chromosome 11.青少年帕金森病与11号染色体上酪氨酸羟化酶基因位点的连锁分析。
Neurology. 1991 May;41(5):719-22. doi: 10.1212/wnl.41.5.719.
7
Absence of linkage between chromosome 11p15 markers and manic-depressive illness in a Belgian pedigree.比利时一个家系中11号染色体p15标记与躁郁症之间不存在连锁关系。
Am J Psychiatry. 1991 Dec;148(12):1683-7. doi: 10.1176/ajp.148.12.1683.
8
Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees.
Am J Psychiatry. 1996 Feb;153(2):271-4. doi: 10.1176/ajp.153.2.271.
9
Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin, and insulin-like growth factor II.人类11号染色体短臂的连锁图谱：过氧化氢酶、降钙素和胰岛素样生长因子II基因的定位
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5064-7. doi: 10.1073/pnas.82.15.5064.
10
Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees.
J Affect Disord. 1991 Jan;21(1):23-32. doi: 10.1016/0165-0327(91)90015-k.

引用本文的文献

1
Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene.后基因组时代与精神疾病的基因发现：这一行有新门道吗？酪氨酸羟化酶基因中HUMTH01微卫星的例子。
Mol Neurobiol. 2002 Oct-Dec;26(2-3):389-403. doi: 10.1385/MN:26:2-3:389.
2
No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family: evidence for genetic heterogeneity.
Hum Genet. 1994 Oct;94(4):364-6. doi: 10.1007/BF00201594.
3
Further RFLPs at the human tyrosine hydroxylase locus.人类酪氨酸羟化酶基因座上的进一步限制性片段长度多态性
Nucleic Acids Res. 1988 Sep 26;16(18):9078. doi: 10.1093/nar/16.18.9078.
4
Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.人类酪氨酸羟化酶基因和胰岛素基因在11号染色体上相邻。
Nucleic Acids Res. 1988 May 25;16(10):4437-46.
5
Tyrosine hydroxylase and levodopa responsive dystonia.酪氨酸羟化酶与左旋多巴反应性肌张力障碍
J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):112-4. doi: 10.1136/jnnp.52.1.112.
6
Comparative map for mice and humans.小鼠与人类的比较图谱。
Mamm Genome. 1991;1 Spec No:S461-515. doi: 10.1007/BF00656504.
7
Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.利用内含子构象多态性对位于11号染色体上的人类色氨酸羟化酶基因进行遗传定位。
Am J Hum Genet. 1992 Dec;51(6):1366-71.
8
Comparative map for mice and humans.小鼠与人类的比较图谱。
Mamm Genome. 1992;3(9):480-536. doi: 10.1007/BF00778825.

本文引用的文献

1
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.人类胰岛素基因附近的高度多态性区域由简单串联重复序列组成。
Nature. 1982 Jan 7;295(5844):31-5. doi: 10.1038/295031a0.
2
The PKU locus in man is on chromosome 12.人类的苯丙酮尿症基因座位于12号染色体上。
Am J Hum Genet. 1984 May;36(3):527-33.
3
Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor.胰岛素样生长因子I和II以及表皮生长因子基因的人类染色体定位
Nature. 1984;310(5980):781-4. doi: 10.1038/310781a0.
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Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.T24人膀胱癌癌基因及其正常同源基因的完整核苷酸序列。
Nature. 1983 Mar 3;302(5903):33-7. doi: 10.1038/302033a0.
5
Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.人胰岛素样生长因子基因的分离：胰岛素样生长因子II与胰岛素基因相邻。
Proc Natl Acad Sci U S A. 1985 Oct;82(19):6450-4. doi: 10.1073/pnas.82.19.6450.
6
Report of the Committee on the Genetic Constitution of Chromosomes 10, 11, and 12.
Cytogenet Cell Genet. 1985;40(1-4):179-205. doi: 10.1159/000132174.
7
A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16.一个与16号染色体上成人多囊肾病相关的高度多态性DNA标记。
Nature. 1985;317(6037):542-4. doi: 10.1038/317542a0.
8
Construction of linkage maps with DNA markers for human chromosomes.构建人类染色体DNA标记连锁图谱。
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酪氨酸羟化酶与11号染色体短臂上的其他四个标记的连锁关系。

Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11.

作者信息

Moss P A, Davies K E, Boni C, Mallet J, Reeders S T

出版信息

Nucleic Acids Res. 1986 Dec 22;14(24):9927-32. doi: 10.1093/nar/14.24.9927.

DOI:10.1093/nar/14.24.9927
PMID:2880337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC341344/
Abstract

Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis; the gene has previously been cloned and localised to the short arm of chromosome 11. Because of the interest in tyrosine hydroxylase as a candidate gene for manic-depressive psychosis and other affective disorders, we carried out family studies to determine the linkage of tyrosine hydroxylase with insulin, beta-globin, D11S12 and Harvey-ras 1, members of a linkage group which has previously been localised to 11p. Using DNA from the Centre d'Etude du Polymorphisme Humain (CEPH) and from two large British pedigrees, we show that tyrosine hydroxylase is closely linked to these four loci (z = 7.36, theta = 0.04 for linkage to insulin) and suggest a gene order based on multipoint mapping.

摘要

酪氨酸羟化酶是儿茶酚胺合成中的限速酶；该基因先前已被克隆并定位于11号染色体短臂。由于对酪氨酸羟化酶作为躁狂抑郁症和其他情感障碍候选基因的关注，我们进行了家系研究，以确定酪氨酸羟化酶与胰岛素、β-珠蛋白、D11S12和哈维-鼠肉瘤病毒1基因（先前已定位于11p的一个连锁群的成员）之间的连锁关系。利用来自人类多态性研究中心（CEPH）以及两个大型英国家系的DNA，我们表明酪氨酸羟化酶与这四个基因座紧密连锁（与胰岛素连锁时z = 7.36，θ = 0.04），并基于多点定位提出了基因顺序。