酪氨酸羟化酶与11号染色体短臂上的其他四个标记的连锁关系。
Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11.
作者信息
Moss P A, Davies K E, Boni C, Mallet J, Reeders S T
出版信息
Nucleic Acids Res. 1986 Dec 22;14(24):9927-32. doi: 10.1093/nar/14.24.9927.
Abstract
Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis; the gene has previously been cloned and localised to the short arm of chromosome 11. Because of the interest in tyrosine hydroxylase as a candidate gene for manic-depressive psychosis and other affective disorders, we carried out family studies to determine the linkage of tyrosine hydroxylase with insulin, beta-globin, D11S12 and Harvey-ras 1, members of a linkage group which has previously been localised to 11p. Using DNA from the Centre d'Etude du Polymorphisme Humain (CEPH) and from two large British pedigrees, we show that tyrosine hydroxylase is closely linked to these four loci (z = 7.36, theta = 0.04 for linkage to insulin) and suggest a gene order based on multipoint mapping.
摘要
酪氨酸羟化酶是儿茶酚胺合成中的限速酶；该基因先前已被克隆并定位于11号染色体短臂。由于对酪氨酸羟化酶作为躁狂抑郁症和其他情感障碍候选基因的关注，我们进行了家系研究，以确定酪氨酸羟化酶与胰岛素、β-珠蛋白、D11S12和哈维-鼠肉瘤病毒1基因（先前已定位于11p的一个连锁群的成员）之间的连锁关系。利用来自人类多态性研究中心（CEPH）以及两个大型英国家系的DNA，我们表明酪氨酸羟化酶与这四个基因座紧密连锁（与胰岛素连锁时z = 7.36，θ = 0.04），并基于多点定位提出了基因顺序。
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