Mao J Y, Li L, Pang Z
Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Zhonghua Yi Xue Za Zhi. 2017 Oct 17;97(38):3001-3004. doi: 10.3760/cma.j.issn.0376-2491.2017.38.011.
To investigate the application value of serum calprotectin in assessing the activity of IBD Eighty-five Crohn's disease(CD) and eighty-five Ulcerative colitis(UC) patients at Suzhou Municipal Hospital(North Branch) from August 2015 to January 2017 were enrolled in this study, and eighty-five healthy subjects were selected as controls. Serum level of calprotectin was determined by ELISA. Correlation of serum calprotectin with clinical features of IBD was analyzed. The diagnostic efficacy for CD and UC were assessed by ROC curve. The level of serum calprotectin was significantly higher in IBD patients than in healthy subjects. Positive correlations were found between serum calprotectin level and CRP, ESR, fecal calprotectin level of IBD(ρ＝0.341, <0.001；ρ＝0.438, <0.001；ρ＝0.542, <0.001，respectively). Besides, positive correlations were found between serum calprotectin level with disease activity index(CDAI or Mayo score) of IBD(ρ＝0.309, ＝0.004；ρ＝0.227, ＝0.036，respectively)．Nevertheless, no correlation was found between serum calprotectin level with location of IBD and disease subtypes(>0.05)．The area under curve(AUC) of serum calprotectin for diagnosis of CD and UC were 0.946 and 0.906, respectively. Serum level of calprotectin is associated with the activity of IBD. As a result，serum level of calprotectin may has the potential to be served as a clinical index of IBD activity.
为探讨血清钙卫蛋白在评估炎症性肠病（IBD）活动度中的应用价值，选取2015年8月至2017年1月在苏州市立医院（北区）就诊的85例克罗恩病（CD）患者和85例溃疡性结肠炎（UC）患者纳入本研究，并选取85例健康受试者作为对照。采用酶联免疫吸附测定法（ELISA）检测血清钙卫蛋白水平。分析血清钙卫蛋白与IBD临床特征的相关性。通过ROC曲线评估其对CD和UC的诊断效能。IBD患者血清钙卫蛋白水平显著高于健康受试者。血清钙卫蛋白水平与IBD患者的C反应蛋白（CRP）、血沉（ESR）、粪便钙卫蛋白水平呈正相关（相关系数ρ分别为0.341，P<0.001；ρ为0.438，P<0.001；ρ为0.542，P<0.001）。此外，血清钙卫蛋白水平与IBD的疾病活动指数（CDAI或梅奥评分）呈正相关（相关系数ρ分别为0.309，P = 0.004；ρ为0.227，P = 0.036）。然而，血清钙卫蛋白水平与IBD的病变部位及疾病亚型之间无相关性（P>0.05）。血清钙卫蛋白诊断CD和UC的曲线下面积（AUC）分别为0.946和0.906。血清钙卫蛋白水平与IBD的活动度相关。因此，血清钙卫蛋白水平有可能作为IBD活动度的一项临床指标。
