Obata Kyoichi, Shimo Tsuyoshi, Okui Tatsuo, Matsumoto Kenichi, Takada Hiroyuki, Takabatake Kiyofumi, Kunisada Yuki, Ibaragi Soichiro, Yoshioka Norie, Kishimoto Koji, Nagatsuka Hitoshi, Sasaki Akira
Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Anticancer Res. 2017 Nov;37(11):6119-6123. doi: 10.21873/anticanres.12060.
BACKGROUND/AIM: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known.
NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model.
NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis.
NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.
背景/目的：神经激肽3受体（NK - 3R）在包括人类口腔鳞状细胞癌在内的中枢神经系统中存在差异表达。然而，NK - 3R信号在口腔鳞状细胞癌中的作用尚不清楚。
采用免疫组织化学方法检测手术切除的口腔鳞状细胞癌中NK - 3R的表达，并对表达强度进行量化。我们在人口腔鳞状细胞癌骨侵袭小鼠模型中使用NK - 3R拮抗剂评估NK - 3R信号的功能。
与口腔侧肿瘤细胞相比，NK - 3R在侵袭骨基质的肿瘤细胞中显著表达。NK - 3R的选择性拮抗剂SB222200显著抑制了影像学上的溶骨性病变和肿瘤发生。
NK - 3R信号是治疗骨破坏情况下口腔鳞状细胞癌的潜在靶点。
