速激肽受体3在人口腔鳞状细胞癌中的分布
Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma.
作者信息
Obata Kyoichi, Shimo Tsuyoshi, Okui Tatsuo, Matsumoto Kenichi, Takada Hiroyuki, Takabatake Kiyofumi, Kunisada Yuki, Ibaragi Soichiro, Nagatsuka Hitoshi, Sasaki Akira
机构信息
Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan
出版信息
Anticancer Res. 2016 Dec;36(12):6335-6341. doi: 10.21873/anticanres.11230.
BACKGROUND
Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown.
MATERIALS AND METHODS
We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis.
RESULTS
We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible.
CONCLUSION
Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.
背景
速激肽3（TAC3）及其主要的速激肽受体3（TACR3）在中枢神经系统中被显著检测到，在生理发育中发挥重要作用，特别是在人类生殖系统中。TAC3/TACR3在口腔鳞状细胞癌中的作用尚不清楚。
材料与方法
我们使用免疫组织化学和免疫荧光分析检测了临床切除的口腔鳞状细胞癌样本中TAC3/TACR3的表达模式。
结果
我们发现，尽管TACR3在正常上皮中的表达水平为阴性，但在肿瘤细胞中高度升高。在迁移到下颌骨基质中的肿瘤细胞侵袭前沿观察到更强的信号。肿瘤细胞中未检测到TAC3，但在下颌骨中PGP-9.5阳性感觉神经中表达。
结论
我们的结果表明，外周感觉神经来源的TAC3可能通过骨基质中的TACR3影响牙龈口腔鳞状细胞癌细胞。
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