肺炎克雷伯菌与人类多形核白细胞的调理素依赖性相互作用的研究。

Investigations on the opsonin-dependent interaction of Klebsiella bacteria and human polymorphonuclear leukocytes.

作者信息

Przondo-Mordarska A, Ko H L, Matej-Melczynska M, Beuth J, Roszkowski W, Pulverer G

机构信息

Microbiological Department, Medical Academy, Wroclaw, Poland.

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Nov;270(1-2):252-9. doi: 10.1016/s0176-6724(88)80161-5.

DOI:10.1016/s0176-6724(88)80161-5

PMID:2906197

Abstract

Encapsulated and nonencapsulated Klebsiella strains with different types of fimbriation were tested for their opsonin-dependent stimulation of human polymorphonuclear leukocytes (PMNs). Chemiluminescence (CL) of the PMNs was determined since CL-response can be used indirectly to quantitate phagocytosis. Apparently, the interaction between Klebsiella bacteria and human PMNs is dependent on the type of fimbration and on the presence of capsules. Evaluation of the bactericidal capacity of human PMNs against Klebsiella bacteria positively correlated with the chemiluminescence response demonstrating the importance of fimbriation and capsulation for this process, too.

摘要

对具有不同菌毛类型的包膜和非包膜克雷伯菌菌株进行了检测，以研究它们对人多形核白细胞（PMN）的调理素依赖性刺激。测定了PMN的化学发光（CL），因为CL反应可间接用于定量吞噬作用。显然，克雷伯菌与人类PMN之间的相互作用取决于菌毛类型和荚膜的存在。评估人PMN对克雷伯菌的杀菌能力与化学发光反应呈正相关，这也证明了菌毛形成和荚膜形成在此过程中的重要性。