一种人类主要组织相容性复合体（MHC）DNA探针可识别山羊基因。
A human major histocompatibility complex (MHC) DNA probe recognizes goat genes.
作者信息
Nesse L L, Paulsen G, Syed M, Ruff G
出版信息
Acta Vet Scand. 1988;29(2):193-8. doi: 10.1186/BF03548370.
Abstract
A human major histocompatibility complex (MHC) class II (DR-β) probe was hybridized with restriction enzyme digest of genomic DNA from 14 goats. Nine of the animals belonged to one family. Digestion of the DNA with the restriction enzyme Eco RI gave 7 fragments in 13 animals and 6 fragments in the last animal. No other polymorphism could be detected. Bam HI digestion gave from 3 to 6 fragments which displayed a considerable polymorphism. In the family studied, polymorphic fragments were inherited together with serologically defined lymphocyte antigen specificities believed to be coded for by MHC class I genes.
摘要
用人主要组织相容性复合体（MHC）Ⅱ类（DR-β）探针与14只山羊的基因组DNA限制性酶切片段进行杂交。其中9只动物属于一个家族。用限制性酶Eco RI消化DNA，13只动物产生7个片段，最后一只动物产生6个片段。未检测到其他多态性。用Bam HI消化产生3至6个片段，显示出相当大的多态性。在所研究的家族中，多态性片段与血清学定义的淋巴细胞抗原特异性一起遗传，这些特异性被认为是由MHCⅠ类基因编码的。
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