通过无金属炔丙基-丙二烯重排和烯丙基迁移合成苯并噻吩和吲哚衍生物。
Synthesis of benzothiophene and indole derivatives through metal-free propargyl-allene rearrangement and allyl migration.
作者信息
Yao Jinzhong, Xie Yajie, Zhang Lianpeng, Li Yujin, Zhou Hongwei
机构信息
College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, P. R. China.
出版信息
Beilstein J Org Chem. 2017 Sep 6;13:1866-1870. doi: 10.3762/bjoc.13.181. eCollection 2017.
Abstract
An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl-allenyl rearrangement followed by cyclization and allyl migration. Phosphine-substituted indoles can be synthesized by a similar strategy.
摘要
本文描述了一种高效的碱催化合成苯并噻吩的方法。该反应通过碱促进的炔丙基-烯丙基重排，随后环化和烯丙基迁移进行。膦取代的吲哚可以通过类似的策略合成。
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