Dailey Wendy A, Drenser Kimberly A, Wong Sui Chien, Cheng Mei, Vercellone Joseph, Roumayah Kevin K, Feeney Erin V, Deshpande Mrinalini, Guzman Alvaro E, Trese Michael, Mitton Kenneth P
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States.
Associated Retinal Consultants, Novi, MI, United States.
Data Brief. 2017 Oct 6;15:491-495. doi: 10.1016/j.dib.2017.09.075. eCollection 2017 Dec.
The data presented in this article are related to the research paper entitled "Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia" (Dailey et al., 2017) [1] This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR). That study utilized Optical coherence tomography (OCT) to visualize retinal layers at high resolution , and to quantify changes to nerve fiber layer thickness. Organization of the laminar structure of other retinal layers in this model , were not known because of uncertainties regarding potential artifacts during the processing of tissue for traditional histology. The OCT image data provided here shows researchers the retinal laminar structural features that exist in this popular mouse OIR model. Traditional H&E stained retinal tissue sections are also provided here for comparison.
本文所呈现的数据与题为《Norrin治疗可改善氧诱导性视网膜缺血模型中的神经节细胞存活》（戴利等人，2017年）[1]的研究论文相关。本文描述了用人Norrin蛋白（一种非典型Wnt蛋白）进行治疗，以改善氧诱导性视网膜病变（OIR）小鼠模型中视网膜神经节细胞的存活情况。该研究利用光学相干断层扫描（OCT）以高分辨率可视化视网膜各层，并量化神经纤维层厚度的变化。由于在传统组织学的组织处理过程中存在潜在伪像的不确定性，该模型中其他视网膜层的层状结构组织情况尚不清楚。此处提供的OCT图像数据向研究人员展示了这种常用小鼠OIR模型中存在的视网膜层状结构特征。此处还提供了传统苏木精-伊红（H&E）染色的视网膜组织切片以供比较。
