大剂量化疗及干细胞救援用于复发性恶性卵巢混合性生殖细胞肿瘤挽救治疗：一例报告
High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report.
作者信息
Sears Sarah, Singh Sareena, Shojaei Hadi, Redline Raymond, Resnick Kimberly
机构信息
Department of Obstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH, USA.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH, USA.
出版信息
Gynecol Oncol Rep. 2017 Sep 29;22:72-74. doi: 10.1016/j.gore.2017.09.013. eCollection 2017 Nov.
BACKGROUND
Malignant ovarian germ cell tumors are rare, and often treatable with surgery and chemotherapy. Few data are available for treatment of platinum-resistant tumors.
CASE
A 31 year old gravida 0 with a 20 cm pelvic mass was found to have a malignant ovarian germ cell tumor after she underwent debulking surgery. She initially responded to chemotherapy; however her AFP began to rise before all cycles were completed. She underwent additional debulking surgery that was again suboptimal. She was then referred for salvage therapy with high-dose chemotherapy with stem cell transplant, which was successful and she has had no evidence of disease for over two years.
CONCLUSION
High-dose chemotherapy with stem cell transplant is a viable salvage therapy for patients with platinum-resistant germ cell tumors.
背景
恶性卵巢生殖细胞肿瘤较为罕见，通常可通过手术和化疗进行治疗。关于铂耐药肿瘤的治疗数据较少。
病例
一名31岁未孕女性，盆腔有一个20厘米的肿块，在接受减瘤手术后被发现患有恶性卵巢生殖细胞肿瘤。她最初对化疗有反应；然而，在所有疗程尚未完成之前，她的甲胎蛋白（AFP）就开始升高。她又接受了一次减瘤手术，但效果仍不理想。随后她被转诊接受高剂量化疗联合干细胞移植的挽救性治疗，治疗成功，且两年多来一直没有疾病迹象。
结论
高剂量化疗联合干细胞移植是铂耐药生殖细胞肿瘤患者可行的挽救性治疗方法。
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