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用炔诺酮替代甲地孕酮治疗转移性子宫内膜癌：三例报告

Norethindrone substituted for megestrol in the treatment of metastatic endometrial carcinoma: Three cases.

作者信息

Read William L, Trivedi Sumita, Williams Felicia

机构信息

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.

Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA, USA.

出版信息

Gynecol Oncol Rep. 2017 Oct 2;22:75-77. doi: 10.1016/j.gore.2017.09.015. eCollection 2017 Nov.

DOI:10.1016/j.gore.2017.09.015
PMID:29062884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5647516/
Abstract

•Progestins can produce clinical benefit in a subset of women with metastatic endometrial cancer.•Corticosteroid-related effects of megestrol can cause morbidity over the long term.•Norethindrone is a progestin without corticosteroid side effects.•A switch from megestrol to norethindrone decreased toxicity with continued benefit.•A clinical trial of norethindrone for this population of patients would be welcome.

摘要

•孕激素可使一部分转移性子宫内膜癌女性患者临床获益。

•甲地孕酮的皮质类固醇相关效应可导致长期发病。

•炔诺酮是一种无皮质类固醇副作用的孕激素。

•从甲地孕酮换用炔诺酮可降低毒性并持续获益。

•欢迎针对该患者群体开展炔诺酮的临床试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eaf/5647516/58cdf4e07a8f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eaf/5647516/28962cb82f94/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eaf/5647516/58cdf4e07a8f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eaf/5647516/28962cb82f94/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eaf/5647516/58cdf4e07a8f/gr2.jpg

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Norethindrone substituted for megestrol in the treatment of metastatic endometrial carcinoma: Three cases.用炔诺酮替代甲地孕酮治疗转移性子宫内膜癌：三例报告
Gynecol Oncol Rep. 2017 Oct 2;22:75-77. doi: 10.1016/j.gore.2017.09.015. eCollection 2017 Nov.
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本文引用的文献

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Therapeutic options for management of endometrial hyperplasia.子宫内膜增生的治疗选择。
J Gynecol Oncol. 2016 Jan;27(1):e8. doi: 10.3802/jgo.2016.27.e8. Epub 2015 Dec 1.
2
Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study.替西罗莫司联合或不联合醋酸甲地孕酮和他莫昔芬治疗子宫内膜癌：一项妇科肿瘤学组研究。
Gynecol Oncol. 2014 Mar;132(3):585-92. doi: 10.1016/j.ygyno.2014.01.015. Epub 2014 Jan 20.
3
The hormonal profile of norethindrone acetate: rationale for add-back therapy with gonadotropin-releasing hormone agonists in women with endometriosis.
醋酸甲羟孕酮的激素谱：内异症患者使用促性腺激素释放激素激动剂加用疗法的理论基础。
Reprod Sci. 2012 Jun;19(6):563-71. doi: 10.1177/1933719112438061. Epub 2012 Mar 27.
4
Classification and pharmacology of progestins.孕激素的分类与药理学
Maturitas. 2008 Sep-Oct;61(1-2):171-80. doi: 10.1016/j.maturitas.2008.11.013.
5
Association between megestrol acetate treatment and symptomatic adrenal insufficiency with hypogonadism in male patients with cancer.醋酸甲地孕酮治疗与男性癌症患者症状性肾上腺皮质功能不全合并性腺功能减退之间的关联。
Cancer. 2007 Sep 15;110(6):1173-7. doi: 10.1002/cncr.22924.
6
Synthetic progestins used in HRT have different glucocorticoid agonist properties.激素替代疗法中使用的合成孕激素具有不同的糖皮质激素激动剂特性。
Mol Cell Endocrinol. 2005 Oct 20;242(1-2):23-32. doi: 10.1016/j.mce.2005.07.001.
7
Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study.醋酸甲地孕酮与他莫昔芬交替方案用于晚期子宫内膜癌的II期试验：一项妇科肿瘤学组的研究
Gynecol Oncol. 2004 Jan;92(1):10-4. doi: 10.1016/j.ygyno.2003.11.008.
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Novel strategies for systemic treatment of endometrial cancer.
Expert Opin Investig Drugs. 2000 Dec;9(12):2831-53. doi: 10.1517/13543784.9.12.2831.
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Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group.醋酸甲羟孕酮口服治疗晚期或复发性子宫内膜癌：妇科肿瘤学组的一项剂量反应研究
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