Hu Youjia, Zhu Baoquan
China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Synth Syst Biotechnol. 2016 Sep 25;1(3):143-149. doi: 10.1016/j.synbio.2016.09.002. eCollection 2016 Sep.
is an important filamentous fungus which produces cephalosporin C in industry. This review summarized the study on genetic engineering of , including biosynthesis and regulation for fermentation of cephalosporin C, molecular techniques, molecular breeding and transcriptomics of . We believe with all the techniques available and full genomic sequence, the industrial strain of can be genetically modified to better serve the pharmaceutical industry.
是一种重要的丝状真菌,在工业上用于生产头孢菌素C。本综述总结了关于其基因工程的研究,包括头孢菌素C的生物合成、发酵调控、分子技术、分子育种和转录组学。我们相信,利用现有的所有技术和完整的基因组序列,可以对其工业菌株进行基因改造,以更好地服务于制药行业。