益生菌与氨基水杨酸盐对溃疡性结肠炎维持治疗效果的比较：一项随机对照试验的荟萃分析。
Comparison of maintenance effect of probiotics and aminosalicylates on ulcerative colitis: A meta-analysis of randomized controlled trials.
作者信息
Jiang Yong, Zhang Zhi-Guang, Qi Feng-Xiang, Zhang Ying, Han Tao
机构信息
Department of Gastroenterology, The Second Hospital of Tianjin Medical University, Ping Jiang Road No 23, He Xi District, Tianjin 300170, China.
Department of Hepatology and Gastroenterology, Tianjin Third Central Hospital of Tianjin Medical University, Jin Tang Road No 83, He Dong District, Tianjin 300170, China.
出版信息
Chronic Dis Transl Med. 2016 Aug 9;2(1):34-41. doi: 10.1016/j.cdtm.2016.07.002. eCollection 2016 Mar.
OBJECTIVE
To evaluate the maintenance effect of probiotics versus that of aminosalicylates on ulcerative colitis.
METHODS
MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the Chinese Biomedical Database were searched in English or Chinese. Data extracted were selected with strict criteria.
RESULTS
In six randomized controlled trials (RCTs), a total of 721 participants were enrolled and the maintenance effect of probiotics ( = 364) versus that of aminosalicylates ( = 357) on ulcerative colitis was investigated. No significant difference was observed between probiotics and aminosalicylate groups (relative risk () = 1.08; 95% confidence interval (): 0.91-1.28; = 0.40). Three RCTs compared the incidence of adverse events with probiotics versus those with aminosalicylates. No significant difference was observed in the incidence of adverse events between the two groups ( = 1.20; 95% : 0.92-1.56; = 0.17).
CONCLUSIONS
Probiotics and aminosalicylates both showed a maintenance effect on ulcerative colitis. However, more well-designed RCTs are required.
目的
评估益生菌与氨基水杨酸盐对溃疡性结肠炎的维持治疗效果。
方法
检索MEDLINE、EMBASE、Cochrane对照试验注册库及中国生物医学数据库，检索语言为英文或中文。严格按照标准选取提取的数据。
结果
在六项随机对照试验（RCT）中，共纳入721名参与者，研究了益生菌（n = 364）与氨基水杨酸盐（n = 357）对溃疡性结肠炎的维持治疗效果。益生菌组与氨基水杨酸盐组之间未观察到显著差异（相对危险度（RR）= 1.08；95%置信区间（CI）：0.91 - 1.28；P = 0.40）。三项RCT比较了益生菌与氨基水杨酸盐的不良事件发生率。两组不良事件发生率未观察到显著差异（RR = 1.20；95%CI：0.92 - 1.56；P = 0.17）。
结论
益生菌和氨基水杨酸盐对溃疡性结肠炎均有维持治疗效果。然而，需要更多设计良好的RCT。
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