Xu Man-Man, Wang Jun, Xie Jun-Xia
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071, China.
Sheng Li Xue Bao. 2017 Oct 25;69(5):598-610.
Hypoxia-inducible factors (HIFs) are central mediators of cellular adaption to hypoxia. The heterodimeric HIF transcription factors consist of HIF-α and HIF-β, that form functional HIFs. Mammals contain HIF-1α, HIF-2α, and HIF-3α. HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR). Hepcidin and iron regulatory proteins (IRPs), the central mediators for systematic and intracellular iron homeostasis, are also regulated by HIFs. In this review, we summarized the regulatory effects of HIFs on iron-related proteins, thus providing insights into the control of HIFs as therapeutic strategies for some iron related disorders.
缺氧诱导因子（HIFs）是细胞适应缺氧的核心介质。异二聚体HIF转录因子由HIF-α和HIF-β组成，它们形成功能性HIFs。哺乳动物含有HIF-1α、HIF-2α和HIF-3α。HIFs通过调节铁相关蛋白的表达在铁代谢中起关键作用，这些蛋白如二价金属转运体1（DMT1）、铁转运蛋白1（FPN1）、十二指肠细胞色素b（Dcytb）和转铁蛋白受体（TfR）。铁调素和铁调节蛋白（IRPs）是系统和细胞内铁稳态的核心介质，它们也受HIFs的调节。在本综述中，我们总结了HIFs对铁相关蛋白的调节作用，从而为将HIFs作为某些铁相关疾病的治疗策略的控制提供见解。
