Cerqueira Raphael O, Frey Benicio N, Leclerc Emilie, Brietzke Elisa
Research Group in Behavioral and Molecular Neuroscience of Bipolar Disorder, Department of Psychiatry, Federal University of São Paulo, Rua Borges Lagoa, 570-10th Floor, Vila Clementino, Sao Paulo, SP, 04038-000, Brazil.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Arch Womens Ment Health. 2017 Dec;20(6):713-719. doi: 10.1007/s00737-017-0791-0. Epub 2017 Oct 23.
The objective of this study was to evaluate whether Vitex agnus castus is a safe and effective treatment for PMS and premenstrual dysphoric disorder (PMDD) and to discuss the implications of these findings for clinical practice. A systematic review of literature was conducted using PubMed and Scielo databases. The inclusion criteria were randomized controlled trials (RCT) using V. agnus castus in individuals with PMS or PMDD that compared this intervention with placebo or an active comparator and included a description of blinding and dropouts/withdrawals. The search was conducted by two independent investigators who reached consensus on the included trials. A total of eight RCTs were included in this study. Most studies focused on PMS, and the diagnostic criteria of PMS and PMDD changed over the years. Three different preparations of V. agnus castus (VAC) were tested, and there was significant variability in the measurement of treatment outcomes between the studies. Nevertheless, all eight studies were positive for VAC in the treatment of PMS or PMDD and VAC was overall well tolerated. Main limitations were differences in definition of diagnostic criteria, the instruments used as main outcome measures, and different preparations of VAC extracts limit the comparison of results between studies. In conclusion, the RCTs using VAC for treatment of PMS/PMDD suggested that the VAC extract is a safe and efficacious alternative to be considered for the treatment of PMS/PMDD symptoms.
本研究的目的是评估贞节树是否是治疗经前综合征（PMS）和经前烦躁障碍（PMDD）的安全有效疗法，并讨论这些研究结果对临床实践的意义。使用PubMed和Scielo数据库对文献进行了系统回顾。纳入标准为针对患有PMS或PMDD的个体使用贞节树进行的随机对照试验（RCT），该试验将这种干预措施与安慰剂或活性对照进行比较，并包括对盲法以及失访/退出情况的描述。检索由两名独立研究人员进行，他们就纳入的试验达成了共识。本研究共纳入八项RCT。大多数研究聚焦于PMS，且多年来PMS和PMDD的诊断标准有所变化。测试了三种不同的贞节树制剂，各研究之间治疗结果的测量存在显著差异。尽管如此，所有八项研究均表明贞节树在治疗PMS或PMDD方面呈阳性结果，且贞节树总体耐受性良好。主要局限性在于诊断标准定义的差异、用作主要结局指标的工具以及贞节树提取物的不同制剂限制了各研究之间结果的比较。总之，使用贞节树治疗PMS/PMDD的RCT表明，贞节树提取物是治疗PMS/PMDD症状可考虑的一种安全有效的替代方法。
