Titov V Yu, Dolgorukova A M, Petrov V A, Osipov A N
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Federal Research Centre All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences, Sergiev Posad, Moscow Region, Russia.
Bull Exp Biol Med. 2017 Oct;163(6):726-730. doi: 10.1007/s10517-017-3890-z. Epub 2017 Oct 24.
The study showed that dinitrosyl iron complex (NO)Fe(RS) containing the thiolate ligands, which is the basic physiological donor of NO, can transfer NO to other molecule only at the moment of rearrangement. This rearrangement can occur during interaction of the complex with more effective iron chelators than the thiolate ligands. In the absence of NO trap, a new complex is formed with a new ligand. NO transfer to a trap can also occur under the action of the agents such as mercury salts or ROS, which interact with the thiolate ligands. Probably, the ligands in the dinitrosyl iron complexes are the structures responsible for interaction of these complexes with physiological targets and for specificity and effectiveness of this interaction.
研究表明，含有硫醇盐配体的二亚硝酰基铁配合物(NO)Fe(RS)是一氧化氮的基本生理供体，它仅在重排瞬间才能将一氧化氮转移至其他分子。这种重排可能发生在该配合物与比硫醇盐配体更有效的铁螯合剂相互作用的过程中。在没有一氧化氮捕获剂的情况下，会与新配体形成一种新的配合物。一氧化氮也可能在汞盐或活性氧等与硫醇盐配体相互作用的试剂作用下转移至捕获剂。二亚硝酰基铁配合物中的配体可能是决定这些配合物与生理靶点相互作用以及这种相互作用的特异性和有效性的结构。
