Iliev A A, Kotov G N, Landzhov B V, Jelev L S, Kirkov V K, Hinova-Palova D V
Department of Anatomy, Histology and Embryology, Medical University of Sofia, Bulgaria.
Folia Morphol (Warsz). 2018;77(2):253-265. doi: 10.5603/FM.a2017.0094. Epub 2017 Oct 24.
Differences in the size of cardiac muscle cells observed in normal and hypertrophic hearts have been assessed through different methodologies. Spontaneously hypertensive rats are often used as an experimental model of essential hypertension in humans, which allows researchers to study the relation between hypertension and cardiac hypertrophy. It has been shown that ventricular hypertrophy in mammals progresses and ventricular failure develops in the end stage of hypertrophy. The aim of the present study was to analyse a number of morphometric markers and compare them between male normotensive Wistar rats (WR) and male spontaneously hypertensive rats (SHR).
The total number of male WR was 15, distributed in five age groups, each containing three animals: 2-week-old; 1-month-old; 3-month--old; 6-month-old; 12-month-old. The male SHR were distributed in two age groups, each containing three animals: 1-month-old (young) and 6-month-old (adult).
As aging progressed, both in male normotensive WR and in male SHR we noted a statistically significant increase in the morphometric parameters thickness of the free wall and the cross-sectional area of the cardiomyocytes and their nuclei and a decrease in the cardiomyocytic density in both ventricles. These changes were more pronounced and occurred at an earlier age in SHR.
The present study analyses in detail the alterations in the myocardium of the left and right ventricle, initiated by age-related hypertrophy, as well as hy-pertrophy induced by arterial hypertension. (Folia Morphol 2018; 77, 2: 253-265).
已通过不同方法评估了在正常心脏和肥厚心脏中观察到的心肌细胞大小差异。自发性高血压大鼠常被用作人类原发性高血压的实验模型，这使研究人员能够研究高血压与心脏肥大之间的关系。研究表明，哺乳动物的心室肥大不断进展，在肥大的终末期会发展为心室衰竭。本研究的目的是分析一些形态测量指标，并在雄性正常血压的Wistar大鼠（WR）和雄性自发性高血压大鼠（SHR）之间进行比较。
雄性WR的总数为15只，分布在五个年龄组中，每组包含三只动物：2周龄；1月龄；3月龄；6月龄；12月龄。雄性SHR分布在两个年龄组中，每组包含三只动物：1月龄（年轻）和6月龄（成年）。
随着年龄的增长，在雄性正常血压的WR和雄性SHR中，我们均注意到形态测量参数（游离壁厚度、心肌细胞及其细胞核的横截面积）在统计学上有显著增加，且两个心室的心肌细胞密度均降低。这些变化在SHR中更为明显且发生得更早。
本研究详细分析了由年龄相关的肥大以及动脉高血压诱导的肥大所引发的左心室和右心室心肌的改变。（《形态学杂志》2018年；77卷，第2期：253 - 265页）
