Vygivska Liudmyla A, Tuchkina Iryna O, Kalnytska Violetta B
Kharkiv National Medical University, Kharkiv, Ukraine.
Wiad Lek. 2017;70(4):731-736.
To study the impact of emergent infections (human herpesvirus type 6) on the fetal state.
The study involved examination of 90 pregnant women in the 2nd and 3rd trimesters of gestation (Group 1 (25 pregnant) consisted of patients with a viral infection, CMV carriers, Group 2 (25 pregnant) included women with a viral infection, herpes simplex virus types 1/2, Group 3 amounted for 20 patients with a viral infection, herpes simplex virus type 6, Group 4 comprised 20 patients with normal pregnancy and no signs of infection. Concentration of IgM and IgG to herpes simplex virus types 1/2, IgM and IgG to herpesvirus type 6 in venous blood of the pregnant was determined by enzyme-immunoassay. Giant cells typical for CMV were determined by cytological examination of saliva sediment. All the pregnant underwent ultrasound somatogenetic examination, Doppler evaluation of maternal-placental-fetal hemodynamics and biophysical profile (BPP) assessment. Results and their discussion: Ultrasound examination of Group 1, 2 and 3 pregnant showed signs of intrauterine infection. Pregnant women with a viral infection were found to have intrauterine growth retardation (IUGR) and Group 3 patients more commonly had symmetrical 3rd degree IUGR. BPP indices showed initial signs of fetal distress in 5 (20%) Group 1 pregnant, 7 (27%) Group 2 pregnant and 11 (55%) Group 3 pregnant women. Doppler examination of uterine-feto-placental hemodynamics revealed a more pronounced increase in vascular resistance indices in Group 3 patients.
Emergent infections (herpesvirus type 6) of pregnant trigger more pronounced changes in the feto-placental system than other viral infections. Herpesvirus type 6 is a common cause of fetal state deterioration, which manifests in intrauterine growth retardation, changes in biophysical profile and hemodynamic disorders in the mother-placenta-fetus system.
研究新发感染（人类疱疹病毒6型）对胎儿状态的影响。
本研究纳入了90例妊娠中期和晚期的孕妇（第1组（25例孕妇）为病毒感染患者、巨细胞病毒携带者，第2组（25例孕妇）包括病毒感染患者，1/2型单纯疱疹病毒感染者，第3组为20例病毒感染患者，6型单纯疱疹病毒感染者，第4组为20例妊娠正常且无感染迹象的患者。通过酶免疫测定法测定孕妇静脉血中针对1/2型单纯疱疹病毒的IgM和IgG、针对6型疱疹病毒的IgM和IgG。通过对唾液沉淀物进行细胞学检查确定典型的巨细胞病毒。所有孕妇均接受超声躯体发育检查、母-胎盘-胎儿血流动力学的多普勒评估和生物物理评分（BPP）评估。结果及其讨论：第1、2和3组孕妇的超声检查显示有宫内感染迹象。发现病毒感染的孕妇有宫内生长受限（IUGR），第3组患者更常见对称性3级IUGR。BPP指标显示，第1组5例（20%）孕妇、第2组7例（27%）孕妇和第3组11例（55%）孕妇有胎儿窘迫的初始迹象。子宫-胎儿-胎盘血流动力学的多普勒检查显示，第3组患者的血管阻力指数升高更为明显。
孕妇的新发感染（6型疱疹病毒）比其他病毒感染在胎儿-胎盘系统中引发更明显的变化。6型疱疹病毒是胎儿状态恶化的常见原因，表现为宫内生长受限、生物物理评分变化以及母-胎盘-胎儿系统的血流动力学紊乱。
