Lev-Tzion Raffi, Assa Amit, Yerushalmi Baruch, Lahad Avishay, Friedman Mira, Ledder Oren, Turner Dan
*Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem†Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv‡Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva§Pediatric Gastroenterology, Hepatology and Nutrition Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer||The Hebrew University of Jerusalem, Jerusalem, Israel.
J Pediatr Gastroenterol Nutr. 2017 Nov;65(5):e101-e103. doi: 10.1097/MPG.0000000000001615.
Pediatric data on rapid infliximab infusion are scarce. We report our experience with a 1-hour rapid infusion protocol, prescribed in 3 pediatric inflammatory bowel disease units during 18 to 26 months. Children treated with infliximab for inflammatory bowel disease using a standard 2- to 3-hour infusion protocol were switched to a 1-hour protocol if they had received at least 4 standard duration infusions with no infusion reactions, there was no recent dose increase and no more than 10 weeks had elapsed since the previous infusion. A total of 102 children received infliximab infusions during the study period (85 Crohn disease; mean age 14.6 ± 2.6 years) of whom 63 were switched to the rapid infusions. Seven patients on the rapid protocol (11%) and 6 patients on the standard protocol (15%) had infusion reactions (P = 0.55). Consistent with adult data, our study indicates that a 1-hour infliximab protocol in selected patients offers a safe alternative to the traditional 2- to 3-hour infusions.
关于英夫利昔单抗快速输注的儿科数据很少。我们报告了我们在18至26个月期间在3个儿科炎症性肠病治疗单元中采用1小时快速输注方案的经验。使用标准2至3小时输注方案治疗炎症性肠病的儿童，如果他们接受了至少4次标准时长输注且无输注反应、近期未增加剂量且自上次输注以来不超过10周，则改为1小时方案。在研究期间，共有102名儿童接受了英夫利昔单抗输注（85例克罗恩病；平均年龄14.6±2.6岁），其中63例改为快速输注。快速方案组有7例患者（11%）出现输注反应，标准方案组有6例患者（15%）出现输注反应（P = 0.55）。与成人数据一致，我们的研究表明，在选定患者中采用1小时英夫利昔单抗方案是传统2至3小时输注的安全替代方案。
