Department of Chemical and Biochemical Engineering, Danish Polymer Centre, Technical University of Denmark, Søltofts Plads Building 229, Kgs. Lyngby, 2800, Denmark.
Department of Chemical and Biochemical Engineering, Center for BioProcess Engineering, Technical University of Denmark, Søltofts Plads Building 229, Kgs. Lyngby, 2800, Denmark.
Macromol Rapid Commun. 2018 Jan;39(2). doi: 10.1002/marc.201700394. Epub 2017 Oct 24.
Thiol-ene (TE)-based polymer particles are traditionally prepared via emulsion polymerization in water (using surfactants, stabilizers, and cosolvents). Here, a green and simple alternative is presented with excellent control over particle size, while avoiding the addition of stabilizers. Glycerol is applied as a dispersing medium for the preparation of off-stoichiometric TE microparticles, where sizes in the range of 40-400 µm are obtained solely by changing the mixing speed of the emulsions prior to crosslinking. Control over surface chemistry is achieved by surface functionalization of excess thiol groups via photochemical thiol-ene chemistry resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization is used for the first time to introduce a thicker polymer layer on the particle surface. The application potential of the system is demonstrated by using functional particles as adsorbent for metal ions and as a support for immobilized enzymes.
巯基-烯（TE）基聚合物颗粒传统上是通过在水中的乳液聚合来制备的（使用表面活性剂、稳定剂和共溶剂）。在这里，提出了一种绿色简单的替代方法，可以极好地控制粒径，同时避免添加稳定剂。甘油被用作制备非化学计量 TE 微球的分散介质，其中通过在交联之前改变乳液的混合速度，可以获得 40-400 µm 范围内的粒径。通过光化学巯基-烯化学反应对过量巯基进行表面功能化，可以实现对表面化学的控制，从而得到功能化单层。此外，首次使用表面链转移自由基聚合在颗粒表面引入较厚的聚合物层。该系统的应用潜力通过将功能颗粒用作金属离子的吸附剂和固定化酶的载体来证明。
