European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Dev Cell. 2017 Oct 23;43(2):113-114. doi: 10.1016/j.devcel.2017.10.006.
During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for self-organization in embryonic patterning.
在斑马鱼原肠胚形成过程中，中胚层祖细胞分化为中胚层或内胚层细胞。在本期《发育细胞》中，Barone 及其同事（2017）表明，细胞间接触持续时间和形态发生素信号之间的相互作用可以控制这种命运分离，为胚胎模式形成中的自我组织提供了一个新的框架。
