Institute for Frontier Life and Medical Sciences, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan; Japan Science and Technology Agency, PRESTO, Saitama 332-0012, Japan.
Department of Information Sciences, Ochanomizu University, Tokyo 112-8610, Japan.
Dev Cell. 2017 Oct 23;43(2):121-123. doi: 10.1016/j.devcel.2017.10.008.
The expression of segmentation clock genes is self-oscillatory due to a delayed negative-feedback mechanism. Hubaud et al. (2017), reporting in Cell, now reveal that segmentation clock genes also exhibit properties of an excitable system, with Yap signaling setting the threshold for adopting an oscillatory state and Notch signaling triggering oscillations.
由于延迟负反馈机制，分段时钟基因的表达具有自振荡特性。Hubaud 等人（2017 年）在《细胞》杂志上的报告现在揭示，分段时钟基因也表现出兴奋系统的特性，Yap 信号为采用振荡状态设定阈值，而 Notch 信号触发振荡。
