Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan.
Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan.
Curr Opin Immunol. 2017 Dec;49:64-70. doi: 10.1016/j.coi.2017.10.002. Epub 2017 Oct 21.
Treg cells expressing the transcription factor Foxp3 are essential for immunological tolerance and homeostasis. Recent genome-wide studies have revealed that Foxp3 natural Treg cells possess a number of unique transcriptional and epigenetic features, which appear to be acquired along the course of Treg cell development and maintained throughout their lifespan. These studies also provide novel insights into how genomic variations contribute to genetic susceptibility to human autoimmune diseases by affecting Treg cell development and function.
表达转录因子 Foxp3 的 Treg 细胞对于免疫耐受和稳态至关重要。最近的全基因组研究表明，Foxp3 自然 Treg 细胞具有许多独特的转录和表观遗传特征，这些特征似乎是在 Treg 细胞发育过程中获得的，并在其整个生命周期中得到维持。这些研究还提供了新的见解，即基因组变异如何通过影响 Treg 细胞的发育和功能来导致人类自身免疫性疾病的遗传易感性。
