纳洛酮和阿片类激动剂对猫迷走神经刺激所致胃兴奋性反应的影响。
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
作者信息
Okamoto T, Kurahashi K, Fujiwara M
机构信息
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
出版信息
Br J Pharmacol. 1988 Oct;95(2):329-34. doi: 10.1111/j.1476-5381.1988.tb11650.x.
Abstract
- An investigation was made into the contribution of endogenous opioids to the initial and delayed excitatory response of the stomach induced by stimulation of the vagal trunk in cats. 2. Naloxone (100 to 1000 micrograms kg-1) had no effect on the initial excitatory response to stimulation of the vagal efferent fibres. However, the same treatment dose-dependently enhanced the delayed excitatory response to stimulation of the vagal afferent fibres. 3. In comparison with the mu-opioid-receptor agonist, [D-Ala2, MePhe4, Gly-ol5]enkephalin and the kappa-opioid-receptor agonist dynorphin A (1-13), lower doses of methionine enkephalin [( Met]enkephalin) markedly inhibited the excitation caused by stimulation of the vagal efferent and afferent fibres. The inhibitory effect of [Met]enkephalin was antagonized by naloxone. 4. The delta-opioid-receptor selective agonist [D-Pen2, D-Pen5]enkephalin mimicked the inhibitory effects of [Met]enkephalin and inhibition by [D-Pen2, D-Pen5]enkephalin was antagonized by the delta-opioid-receptor antagonist, ICI 174,864. 5. It is concluded that the inhibitory effects of exogenous opioids on the excitatory response of the stomach to stimulation of the vagal efferent and afferent fibres are mediated, at least in part, by delta-opioid-receptors. Naturally occurring opioids may participate in the inhibition of the delayed gastric excitation to stimulation of the vagal afferent fibres.
摘要
- 研究了内源性阿片类物质对猫迷走神经干刺激引起的胃初始和延迟兴奋反应的作用。2. 纳洛酮（100至1000微克/千克）对迷走神经传出纤维刺激的初始兴奋反应无影响。然而，相同的治疗剂量依赖性地增强了对迷走神经传入纤维刺激的延迟兴奋反应。3. 与μ-阿片受体激动剂[D-Ala2，MePhe4，Gly-ol5]脑啡肽和κ-阿片受体激动剂强啡肽A（1-13）相比，较低剂量的甲硫氨酸脑啡肽[（Met）脑啡肽]显著抑制了迷走神经传出和传入纤维刺激引起的兴奋。[Met]脑啡肽的抑制作用被纳洛酮拮抗。4. δ-阿片受体选择性激动剂[D-Pen2，D-Pen5]脑啡肽模拟了[Met]脑啡肽的抑制作用，[D-Pen2，D-Pen5]脑啡肽的抑制作用被δ-阿片受体拮抗剂ICI 174,864拮抗。5. 得出结论，外源性阿片类物质对胃对迷走神经传出和传入纤维刺激的兴奋反应的抑制作用至少部分由δ-阿片受体介导。天然存在的阿片类物质可能参与对迷走神经传入纤维刺激引起的延迟胃兴奋的抑制。
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