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用于电磁和肾上腺素刺激的运动动力学研究的鼠心室心脏组织模型。

Model of Murine Ventricular Cardiac Tissue for Kinematic-Dynamic Studies of Electromagnetic and -Adrenergic Stimulation.

机构信息

Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.

Centre for Health Technologies (CHT), University of Pavia, Pavia, Italy.

出版信息

J Healthc Eng. 2017;2017:4204085. doi: 10.1155/2017/4204085. Epub 2017 Aug 8.

DOI:10.1155/2017/4204085
PMID:29065600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5591919/
Abstract

In a model of murine ventricular cardiac tissue , we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 M), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the -adrenergic effect of isoproterenol and to elicit an antihypertrophic response.

摘要

在一项关于鼠心室心肌组织的模型研究中，我们研究了电磁刺激（频率为 75 Hz）、异丙肾上腺素给药（10 μM）及其联合应用的变力效应。具体来说，我们进行了图像处理分析，从收缩运动的视频记录中评估跳动心肌细胞的运动学和动力学。我们发现，电磁刺激能够拮抗异丙肾上腺素的β肾上腺素能效应，并引发抗肥厚反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/87d13ff777a5/JHE2017-4204085.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/69c1a3bbd50e/JHE2017-4204085.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/ea35769dc00b/JHE2017-4204085.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/86ef15d0d507/JHE2017-4204085.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/875963268c8b/JHE2017-4204085.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/401b16f9cbc2/JHE2017-4204085.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/87d13ff777a5/JHE2017-4204085.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/69c1a3bbd50e/JHE2017-4204085.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/ea35769dc00b/JHE2017-4204085.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/86ef15d0d507/JHE2017-4204085.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/875963268c8b/JHE2017-4204085.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/401b16f9cbc2/JHE2017-4204085.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3342/5591919/87d13ff777a5/JHE2017-4204085.006.jpg

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本文引用的文献

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Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's Disease.低频脉冲电磁场能够调节阿尔茨海默病实验细胞模型中的 miRNAs。
J Healthc Eng. 2017;2017:2530270. doi: 10.1155/2017/2530270. Epub 2017 May 2.
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Pulsed Electromagnetic Field with Temozolomide Can Elicit an Epigenetic Pro-apoptotic Effect on Glioblastoma T98G Cells.脉冲电磁场联合替莫唑胺可对胶质母细胞瘤T98G细胞产生表观遗传促凋亡作用。
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β-Adrenergic response is counteracted by extremely-low-frequency pulsed electromagnetic fields in beating cardiomyocytes.
在跳动的心肌细胞中，极低频脉冲电磁场可抵消β-肾上腺素能反应。
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Pulsed electromagnetic field (PEMF) prevents pro-oxidant effects of H2O2 in SK-N-BE(2) human neuroblastoma cells.脉冲电磁场（PEMF）可防止H2O2对人神经母细胞瘤SK-N-BE(2)细胞产生促氧化作用。
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