Department of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, Belgium.
Department of Respiratory Medicine, Ghent University Hospital and Ghent University, Ghent, Belgium.
Crit Rev Oncol Hematol. 2017 Nov;119:40-49. doi: 10.1016/j.critrevonc.2017.09.014. Epub 2017 Sep 28.
Lung cancer and its treatment have an important impact on the patients' health-related quality-of-life (HRQoL). A systematic literature review of prospective clinical studies published since 2005 and measuring HRQoL in patients with locally-advanced non-small cell lung cancer (LA- NSCLC) was performed. Besides reviewing the HRQoL impact of LA-NSCLC treatment, it critically examined the frequency, methodology and quality of HRQoL data collection and analysis in LA-NSCLC clinical studies. Out of 814 potentially eligible publications, only 27 (representing 19 individual studies) met the inclusion criteria. Eight studies documented an impact on HRQoL. Large variability in use of HRQoL instruments, statistical analysis and methodological quality was observed. Reporting of HRQoL data lacks standardization, but recent initiatives establishing recommendations to standardize the analysis and reporting of HRQoL in cancer trials are expected to address these issues. Overall, more research is needed to evaluate the treatment impact on HRQoL in both clinical trials and daily care.
肺癌及其治疗对患者的健康相关生活质量（HRQoL）有重要影响。对 2005 年以来发表的前瞻性临床研究进行了系统的文献回顾，以测量局部晚期非小细胞肺癌（LA-NSCLC）患者的 HRQoL。除了审查 LA-NSCLC 治疗对 HRQoL 的影响外，还对 LA-NSCLC 临床研究中 HRQoL 数据收集和分析的频率、方法和质量进行了批判性评估。在 814 篇潜在合格的出版物中，只有 27 篇（代表 19 项单独的研究）符合纳入标准。有 8 项研究记录了对 HRQoL 的影响。观察到 HRQoL 工具的使用、统计分析和方法学质量存在很大差异。HRQoL 数据的报告缺乏标准化，但预计最近的一些举措将建立癌症试验中 HRQoL 分析和报告的标准化建议来解决这些问题。总体而言，需要更多的研究来评估临床试验和日常护理中治疗对 HRQoL 的影响。
