Department of Cellular and Physiological SciencesUniversity of British Columbia, British Columbia, Canada
Department of Obstetrics and GynaecologyUniversity of British Columbia, British Columbia, Canada.
Reproduction. 2018 Feb;155(2):R93-R104. doi: 10.1530/REP-17-0281. Epub 2017 Oct 24.
The endoplasmic reticulum (ER) forms a continuous network throughout morphologically differentiated Sertoli cells. It is an integral component of intercellular adhesion junctions in this cell type, as well as forming membrane contact sites with the plasma membrane and intracellular organelles. One of the major functions of the ER in cells generally is maintaining calcium homeostasis and generating calcium signals. In this review, we discuss what is currently known about the overall pattern of distribution of the ER in Sertoli cells and the location of calcium regulatory machinery in the various subdomains of the organelle. Current data are consistent with the hypothesis that calcium signaling by the ER of Sertoli cells may play a significant role in events related to junction remodeling that occur in the seminiferous epithelium during spermatogenesis.
内质网（ER）在形态分化的支持细胞中形成一个连续的网络。它是这种细胞类型中细胞间黏附连接的组成部分，同时还与质膜和细胞内细胞器形成膜接触位点。内质网在细胞中的主要功能之一是维持钙离子的动态平衡和产生钙离子信号。在这篇综述中，我们讨论了目前已知的支持细胞中内质网的总体分布模式，以及钙调节机制在细胞器各个亚区的位置。目前的数据与内质网钙信号可能在精子发生过程中生精上皮中发生的连接重塑事件中发挥重要作用的假说一致。
