Lopez Adriana S, Lanzieri Tatiana M, Claussen Angelika H, Vinson Sherry S, Turcich Marie R, Iovino Isabella R, Voigt Robert G, Caviness A Chantal, Miller Jerry A, Williamson W Daniel, Hales Craig M, Bialek Stephanie R, Demmler-Harrison Gail
National Center for Immunization and Respiratory Diseases, and.
National Center for Immunization and Respiratory Diseases, and
Pediatrics. 2017 Nov;140(5). doi: 10.1542/peds.2017-1517.
To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants.
We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing ( = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age ( = 11) and controls ( = 40).
Patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared with controls, but no significant differences were noted in these scores among patients with normal hearing and controls. No significant differences were noted in scores for verbal and nonverbal intelligence, expressive vocabulary, and academic achievement in math and reading among patients with normal hearing or with SNHL and controls.
Infants with asymptomatic congenital cytomegalovirus infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in IQ, vocabulary or academic achievement scores during childhood, or adolescence compared with uninfected children.
通过基于医院的新生儿筛查确定的先天性巨细胞病毒感染且出生时无症状的儿童，与未感染婴儿相比，研究其18岁前的智力、语言和学业成绩。
我们使用生长曲线模型分析智商（全量表、言语和非言语智力）、接受性和表达性词汇以及数学和阅读学业成绩的趋势。针对每个结果拟合单独的模型，对听力正常（n = 78）或2岁前诊断为感音神经性听力损失（SNHL）（n = 11）的患者以及对照组（n = 40），随着年龄增长总体得分的变化进行建模。
与对照组相比，SNHL患者的全量表智力和接受性词汇得分分别低7.0分和13.1分，但听力正常的患者与对照组在这些得分上未发现显著差异。听力正常或患有SNHL的患者与对照组在言语和非言语智力、表达性词汇以及数学和阅读学业成绩得分上均未发现显著差异。
通过新生儿筛查确定的2岁时听力正常的无症状先天性巨细胞病毒感染婴儿，与未感染儿童相比，在儿童期或青春期的智商、词汇或学业成绩得分上似乎没有差异。
