[中性粒细胞与淋巴细胞比值对食管癌食管切除术后患者预后的影响]

[The Impact of Neutrophil-Lymphocyte Ratio on the Prognosis in Patients Who Underwent Esophagectomy for Esophageal Cancer].

作者信息

Muroya Takahiro, Wajima Naoki, Ogasawara Hiroshi, Yachi Takafumi, Akaishi Takanobu, Umetsu Satoko, Wakasa Yusuke, Yoshida Tatsuya, Sato Kentaro, Mitsuhashi Yuto, Umemura Kotaro, Suzuki Takahiro, Tsuruta Satoru, Hakamada Kenichi

机构信息

Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.

出版信息

Gan To Kagaku Ryoho. 2017 Oct;44(10):912-914.

PMID:29066693

Abstract

BACKGROUND

Thene utrophil-lymphocyteratio (NLR)reflects a patient's systemic inflammatory response. Several studies have revealed that the NLR is associated with a poor prognosis in several types of malignant tumors such as colorectal and lung cancer. The aim of this study was to evaluate the impact of preoperative NLR on the prognosis of patients with esophageal cancer.

METHODS

The NLR was calculated for 93 consecutive patients with clinical Stage II or III esophageal cancer, who underwent curative esophagectomy following neoadjuvant chemotherapy between 2011 and 2013. The impact of preoperativeNLR on overall survival(OS)after esophagectomy was evaluated. The NLR cut off value was set to 2.

RESULTS

The 3-year OS of patients with NLR≥2 was significantly shorter than patients with NLR<2(40.5% vs 67.9%, p=0.005). In a multivariateCox model, NLR≥2(HR: 2.342, 95%CI: 1.095-5.007, p=0.028), pathological depth of tumor(HR: 3.207, 95%CI: 1.114- 9.233, p=0.031), and an ageove r 60(HR: 2.342, 95%CI: 1.117-6.501, p=0.027)were identified as independent prognostic factors for OS after esophagectomy.

CONCLUSIONS

The preoperative NLR was significantly associated with a poor prognosis in esophageal cancer patients who underwent curative esophagectomy following neoadjuvant chemotherapy.

摘要

背景

中性粒细胞与淋巴细胞比值（NLR）反映患者的全身炎症反应。多项研究表明，NLR与结直肠癌和肺癌等多种恶性肿瘤的预后不良相关。本研究旨在评估术前NLR对食管癌患者预后的影响。

方法

对2011年至2013年间93例连续的临床II期或III期食管癌患者进行了NLR计算，这些患者在新辅助化疗后接受了根治性食管切除术。评估术前NLR对食管切除术后总生存期（OS）的影响。NLR临界值设定为2。

结果

NLR≥2的患者3年总生存期明显短于NLR<2的患者（40.5%对67.9%，p = 0.005）。在多因素Cox模型中，NLR≥2（HR：2.342，95%CI：1.095 - 5.007，p = 0.028）、肿瘤病理深度（HR：3.207，95%CI：1.114 - 9.233，p = 0.031）和年龄大于60岁（HR：2.342，95%CI：1.117 - 6.501，p = 0.027）被确定为食管切除术后总生存期的独立预后因素。