Xiaoqian Zhou, Tao Zhang, Bingsong Luo, Jing Li, Yu Deng, Weilan Zhong
Dr. Zhou Xiaoqian, Department of Gastroenterology, The First People's Hospital of Gui Yang, Gui Zhou Province, China.
Dr. Zhang Tao, Department of Gastroenterology, The First People's Hospital of Gui Yang, Gui Zhou Province, China.
Pak J Med Sci. 2017 Jul-Aug;33(4):891-894. doi: 10.12669/pjms.334.12290.
To investigate the Clinical practice value of nitrous oxide inhalation and intravenous propofol and midazolam sedation in transnasal gastroscopy.
From December 2012 to April 2014, two hundred patients receiving painless transnasal gastroscopy on a voluntary basis were selected in Endoscopy center, The First People's Hospital of GuiYang. Patients were divided into two groups: Group-1 consisted of one hundred patients sedated by nitrous oxide inhalation and Group-2 consisted of one hundred patients sedated by intravenous propofol and midazolam. Patients were then examined by transnasal gastroscopy. Patient blood pressure, heart rate, pulse rate and oxygen saturation before, during and after gastroscopy were recorded for both groups. The duration of the gastroscopy and the time of awakening were also recorded. After examination, the patients were asked to assess the level of discomfort experiences during the gastroscopy procedure.
All patients successfully underwent the transnasal gastroscopy. There were 57 males and 43 females in the nitrous oxide inhalation group with an average age of 43.11±8.27 years. The average duration of examination and time of awaking in the nitrous oxide inhalation group was of 152.7±9.80 secs and 50±7.89 secs respectively. For the intravenous propofol and midazolam sedation group, there were 53 males and 47 females with an average age of 41.26±7.98 years. The average duration of examination and time of awaking in the intravenous propofol and midazolam sedation group was of 149.07±10.25 seconds and 390±20.89 seconds respectively. The two groups showed no significant difference in the duration of examination. There was no difference in the age or sex. The former had a less significant impact on heart rate, oxygen saturation and blood pressure, while the intravenous propofol and midazolam sedation decreased blood pressure dramatically and this effect persisted after examination.
Nitrous oxide inhalation has higher safety and tolerance with a brighter application prospect for transnasal gastroscopy.
探讨氧化亚氮吸入与静脉注射丙泊酚和咪达唑仑镇静在经鼻胃镜检查中的临床应用价值。
选取2012年12月至2014年4月在贵阳市第一人民医院内镜中心自愿接受无痛经鼻胃镜检查的200例患者。将患者分为两组：第一组100例采用氧化亚氮吸入镇静，第二组100例采用静脉注射丙泊酚和咪达唑仑镇静。然后对患者进行经鼻胃镜检查。记录两组患者胃镜检查前、检查期间及检查后的血压、心率、脉搏率和血氧饱和度。同时记录胃镜检查持续时间和苏醒时间。检查后，要求患者评估胃镜检查过程中的不适程度。
所有患者均成功完成经鼻胃镜检查。氧化亚氮吸入组男性57例，女性43例，平均年龄43.11±8.27岁。氧化亚氮吸入组平均检查持续时间和苏醒时间分别为152.7±9.80秒和50±7.89秒。静脉注射丙泊酚和咪达唑仑镇静组男性53例，女性47例，平均年龄41.26±7.98岁。静脉注射丙泊酚和咪达唑仑镇静组平均检查持续时间和苏醒时间分别为149.07±10.25秒和390±20.89秒。两组检查持续时间无显著差异。年龄和性别无差异。前者对心率、血氧饱和度和血压的影响较小，而静脉注射丙泊酚和咪达唑仑镇静使血压显著下降，且检查后这种影响仍持续存在。
氧化亚氮吸入用于经鼻胃镜检查具有较高的安全性和耐受性，应用前景广阔。
