Bartram David J, Moyaert Hilde, Vanimisetti Bindu H, Ramage Clifford P, Reddick David, Stegemann Michael R
ZoetisMercuriusstraat 20Zaventem1930Belgium.
Zoetis333 Portage StreetKalamazoo49007Michigan, United States.
Vet Med Sci. 2016 May 14;2(3):170-178. doi: 10.1002/vms3.31. eCollection 2016 Aug.
The objective of this negative controlled, blinded, randomised, parallel group study was to compare the efficacy of two injectable macrolide antimicrobials, tulathromycin and tildipirosin, administered by single subcutaneous injection at dose rates of 2.5 and 4.0 mg kg bodyweight, respectively, in the treatment of an experimentally induced infection in calves. A total of 238 negative calves were challenged on three consecutive days with by endobronchial deposition. Post-challenge, a total of 126 animals fulfilled the inclusion criteria and were randomly allocated to three treatment groups: tulathromycin, tildipirosin and saline. Clinical observations for signs of respiratory disease and injection site assessments were conducted daily for 14 days post-treatment. The animals were then killed, the lungs were examined for evidence of lesions, and samples collected for bacterial isolation. Calves treated with tulathromycin had a lower percentage of lung with lesions (=0.0079), lower mortality (=0.0477), fewer days with depressed demeanour (=0.0486) and higher body weight (=0.0112) than calves administered tildipirosin.
这项阴性对照、双盲、随机、平行组研究的目的是比较两种注射用大环内酯类抗菌药物——妥拉霉素和替地珠单抗，分别以2.5毫克/千克和4.0毫克/千克体重的剂量率进行单次皮下注射，在治疗犊牛实验性诱导感染中的疗效。总共238头阴性犊牛连续三天通过支气管内沉积进行攻毒。攻毒后，共有126只动物符合纳入标准，并被随机分配到三个治疗组：妥拉霉素组、替地珠单抗组和生理盐水组。在治疗后的14天内，每天进行呼吸道疾病体征的临床观察和注射部位评估。然后处死动物，检查肺部有无病变证据，并采集样本进行细菌分离。与接受替地珠单抗治疗的犊牛相比，接受妥拉霉素治疗的犊牛肺部病变百分比更低（P=0.0079），死亡率更低（P=0.0477），萎靡不振天数更少（P=0.0486），体重更高（P=0.0112）。
