在一个杂合子表现出视网膜毯反射的家系中，X连锁视网膜色素变性基因座定位于DXS7和DXS84之间。
Localization of the X-linked retinitis pigmentosa locus between DXS7 and DXS84 in a family showing tapetal reflex in heterozygotes.
作者信息
Chen J D, Halliday F, Serravalle S, Denton M
机构信息
Department of Clinical Chemistry, Prince of Wales Hospital, Randwick, NSW, Australia.
出版信息
Ophthalmic Paediatr Genet. 1988 Nov;9(3):143-7. doi: 10.3109/13816818809031490.
The linkage relationships between the X-linked retinitis pigmentosa (XLRP) locus and seven Xp loci: DXS14, DXS7, OTC, DXS141, DXS148, DXS84 and DXS206 were analysed in one large family in which the heterozygotes exhibited the tapetal reflex. Evidence drawn from two-point and multipoint linkage analysis and a number of triply informative crossovers suggests that the XLRP locus in this family is between DXS7 and DXS84. The putative order of loci on the short arm of the X chromosome is: centromere - DXS14 - DXS7 - OTC - XLRP/DXS141 - DXS148 - DXS84 - DXS206 - telemere.
在一个杂合子表现出视网膜毯反射的大家系中，分析了X连锁视网膜色素变性（XLRP）基因座与7个Xp基因座：DXS14、DXS7、鸟氨酸转氨甲酰酶（OTC）、DXS141、DXS148、DXS84和DXS206之间的连锁关系。两点和多点连锁分析以及一些三重信息交换得出的证据表明，该家系中的XLRP基因座位于DXS7和DXS84之间。X染色体短臂上基因座的推定顺序为：着丝粒 - DXS14 - DXS7 - OTC - XLRP/DXS141 - DXS148 - DXS84 - DXS206 - 端粒。
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