Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Mol Med Rep. 2017 Aug;16(2):1007-1013. doi: 10.3892/mmr.2017.6718. Epub 2017 Jun 7.
Preeclampsia (PE) is one of the most common types of hypertensive disease and occurs in 3‑4% of pregnancies. There are a number of theories on the pathogenesis of PE. Abnormal differentiation of the placenta may lead to failure of trophoblast migration, shallow placenta implantation and placental ischemia/hypoxia, followed by the subsequent occurrence of PE. The Wnt/β-catenin pathway is a canonical Wnt‑signaling pathway that regulates several biological processes, including proliferation, migration, invasion and apoptosis. Abnormal activation of the Wnt/β‑catenin signaling pathway may serve an important role in the pathogenesis of various human diseases, particularly in human cancer. Recent studies have demonstrated that the dysregulation of the Wnt/β‑catenin signaling pathway may contribute to PE. The present review aims to summarize the articles on Wnt/β‑catenin signaling pathway in the trophoblast and abnormal activation in PE. Wnt/β-catenin signaling may serve a significant role in the pathogenesis of PE and may be a prospective therapeutic target for the prevention and treatment of PE.
子痫前期 (PE) 是最常见的高血压疾病之一，约占妊娠的 3-4%。PE 的发病机制有许多理论。胎盘的异常分化可能导致滋养细胞迁移失败、胎盘浅着床和胎盘缺血/缺氧，随后发生 PE。Wnt/β-catenin 通路是一种经典的 Wnt 信号通路，调节包括增殖、迁移、侵袭和凋亡在内的多种生物学过程。Wnt/β-catenin 信号通路的异常激活可能在各种人类疾病的发病机制中发挥重要作用，特别是在人类癌症中。最近的研究表明，Wnt/β-catenin 信号通路的失调可能导致 PE。本综述旨在总结关于滋养细胞中 Wnt/β-catenin 信号通路及其在 PE 中的异常激活的文章。Wnt/β-catenin 信号通路可能在 PE 的发病机制中发挥重要作用，并且可能是预防和治疗 PE 的有前途的治疗靶点。
