Reeves Ryan R, Walters Daniel, Mahmud Ehtisham
Sulpizio Cardiovascular Center, University of California, San Diego, La Jolla, California.
Catheter Cardiovasc Interv. 2018 Mar 1;91(4):760-764. doi: 10.1002/ccd.27259. Epub 2017 Oct 25.
Renal artery stenosis (RAS) is a prevalent cause of secondary hypertension. Elderly patients with atherosclerosis and young women with fibromuscular dysplasia (FMD) are particularly at risk. Blood pressure screening is often key to this diagnosis, although the reliability of clinical screening has been questioned, and ambulatory blood pressure monitoring (ABPM) likely offers superior ability to diagnose poorly controlled hypertension. In patients with RAS, medical management should be the primary means of therapy; however, in a select group of these patients, renal revascularization may be considered, and has been shown to reduce blood pressure and stabilize chronic kidney disease. In this report, we present a patient diagnosed with RAS due to FMD, found to have significant hypertension via ABPM, and treated successfully with percutaneous renal artery angioplasty; importantly, continuous 24-hr ambulatory monitoring after pressure gradient guided renal angioplasty confirmed reduction in blood pressure.
肾动脉狭窄(RAS)是继发性高血压的常见病因。患有动脉粥样硬化的老年患者和患有纤维肌发育不良(FMD)的年轻女性尤其危险。血压筛查通常是该诊断的关键,尽管临床筛查的可靠性受到质疑,而动态血压监测(ABPM)可能具有更好的能力来诊断控制不佳的高血压。在RAS患者中,药物治疗应是主要治疗手段;然而,在这些患者中的特定群体中,可考虑进行肾血管重建术,并已证明该手术可降低血压并稳定慢性肾病。在本报告中,我们介绍了一名因FMD被诊断为RAS的患者,通过ABPM发现患有严重高血压,并经皮肾动脉血管成形术成功治疗;重要的是,在压力梯度引导的肾血管成形术后进行连续24小时动态监测证实血压有所降低。