Sacchetti L, Castaldo G, Cimino L, Budillon G, Salvatore F
Istituto di Scienze Biochimiche, Università di Napoli, Italy.
Clin Chim Acta. 1988 Oct 14;177(2):167-72. doi: 10.1016/0009-8981(88)90138-6.
Total GGT and GGT complexed with low-density-lipoprotein plus very low-density lipoprotein (LDL + VLDL) have been evaluated in sera from 53 healthy subjects, 23 patients with chronic hepatitis, 87 with liver cirrhosis and 50 with liver tumors (primary and metastatic). A cut-off of 20 U/l of GGT complexed with LDL + VLDL results in a diagnostic sensitivity of 84% for liver tumor patients, and a diagnostic specificity of about 80% towards the two groups of patients affected by cirrhosis or chronic hepatitis. This test, because of its high diagnostic efficiency, is a useful addition to the battery of laboratory tests that serve to discriminate cirrhosis and chronic hepatitis from liver malignancies.
对53名健康受试者、23名慢性肝炎患者、87名肝硬化患者和50名肝肿瘤（原发性和转移性）患者的血清进行了总谷氨酰转肽酶（GGT）以及与低密度脂蛋白加极低密度脂蛋白（LDL + VLDL）结合的GGT的评估。与LDL + VLDL结合的GGT临界值为20 U/l时，对肝肿瘤患者的诊断敏感性为84%，对肝硬化或慢性肝炎两组患者的诊断特异性约为80%。由于该检测具有较高的诊断效率，因此是用于区分肝硬化、慢性肝炎和肝脏恶性肿瘤的一系列实验室检测中的一项有用补充。
