Department of Neurology, Clinic of Optic Neuritis and Clinic of Multiple Sclerosis, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Acta Neurol Scand. 2017 Nov;136 Suppl 201:49-51. doi: 10.1111/ane.12837.
An association between certain vaccinations and onset or relapse of multiple sclerosis (MS) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis (ON). Case studies were excluded. With the exception of a live vaccine against yellow fever, vaccinations appear safe in untreated patients with MS and ON. However, most studies were underpowered, and small risks cannot be excluded. One study of BCG vaccination after the first demyelinating event showed even a reduced risk of developing MS. Further studies are needed to fully exclude a causal association.
某些疫苗接种与多发性硬化症（MS）的发病或复发之间的关联一直存在争议。基于 PubMed，我们进行了全面的文献综述，纳入了所有相关研究，其中 51 项研究针对 MS，15 项研究针对视神经炎（ON）。排除了病例研究。除了针对黄热病的活疫苗外，疫苗在未经治疗的 MS 和 ON 患者中似乎是安全的。然而，大多数研究的效力不足，不能排除较小的风险。一项针对首次脱髓鞘事件后接种卡介苗的研究甚至表明，发生 MS 的风险降低。需要进一步的研究来完全排除因果关联。
