Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University, Nanjing, 210023, China.
Macromol Biosci. 2017 Dec;17(12). doi: 10.1002/mabi.201700206. Epub 2017 Oct 25.
Cisplatin-rich supramolecular nanoparticles are constructed through the supramolecular inclusion interaction between the admantyl (Ad)-terminated poly(aspartic acid) (Ad-P(Asp)) and the β-cyclodextrin (β-CD)-terminated poly(2-methyl-2-oxazoline). In the formation of the nanoparticles, the β-CD/admantane inclusion complex integrates poly(2-methyl-2-oxazoline) and poly(aspartic acid) chains to form pseudoblock copolymers, followed by the coordination between carboxyl groups in P(Asp) block and cisplatin. This coordination interaction drives the formation of nanoparticle and enables cisplatin incorporated into the nanoparticles. The spherical cisplatin-rich supramolecular nanoparticles have 53% cisplatin-loading content, good stability, and effective inhibition of the cell proliferation when it is tested in H22 cancer cells. Near-infrared fluorescence imaging of tumor bearing mice reveals that the cisplatin-rich nanoparticles can target the tumor in vivo effectively.
顺铂富超分子纳米粒子是通过金刚烷基（Ad）封端聚天冬氨酸（Ad-P（Asp））和β-环糊精（β-CD）封端聚（2-甲基-2-恶唑啉）之间的超分子包合相互作用构建的。在纳米粒子的形成过程中，β-CD/金刚烷包合物将聚（2-甲基-2-恶唑啉）和聚天冬氨酸链整合在一起，形成伪嵌段共聚物，然后是 P（Asp）块中的羧基与顺铂之间的配位。这种配位相互作用促使纳米粒子的形成，并使顺铂掺入纳米粒子中。球形顺铂富超分子纳米粒子具有 53%的顺铂载药含量、良好的稳定性和对 H22 癌细胞增殖的有效抑制作用。荷瘤小鼠的近红外荧光成像表明，顺铂富纳米粒子可以在体内有效地靶向肿瘤。
