Zengin Orhan, Yıldız Hamit, Demir Zeynep Hanım, Dağ Muhammed Sait, Aydınlı Musa, Onat Ahmet Mesut, Kısacık Bünyamin
Faculty of Medicine, Gaziantep University, Turkey.
Department of İnternal Medicine, School of Medicine, Gaziantep University, Turkey.
Adv Clin Exp Med. 2017 Sep;26(6):987-990. doi: 10.17219/acem/63095.
Viruses are common and are involved in the etiology of idiopathic rheumatological diseases. Hepatitis B virus (HBV), a member of the family Hepadnaviridae and hepatitis C virus (HCV), play an important role in the undetermined etiology of arthritis. The clinical manifestations of hepatitis B and C show similarities with various diseases, such as rheumatic diseases. Anti-cyclic citrullinated peptide (anti-CCP) is a specific serological marker for rheumatoid arthritis.
The aim of this study was to analyze anti-CCP and rheumatoid factor (RF) levels in patients with a hepatitis B and C infection.
Forty-four patients with hepatitis B, 43 patients with hepatitis C, 25 patients with rheumatoid arthritis, and 46 healthy control serums and their RF and anti-CCP levels were compared. RF was measured by the nephelometer, which detects IgM-RF. Anti-CCP was measured using enzymelinked immunosorbent assay (ELISA) that is included in the second-generation anti-CCP antibody assays (anti-CCP2).
The anti-CCP positivity levels were 20.5%, 32.5%, 72.4% and 10.9% for HBV, HCV and RA groups and healthy control group, respectively. When the groups were compared based on their RF positivity and anti-CCP positivity while the values for HBV and HCV group and healthy control group were the same, in RA group there is a significant difference to the rest of the groups (p < 0.01).
Anti-CCP may be positive for HBV and HCV as well, but it is a sensitive and specific immunological marker for RA diagnosis, especially in high-titres.
病毒很常见，且与特发性风湿性疾病的病因有关。乙型肝炎病毒（HBV）是嗜肝DNA病毒科的成员，丙型肝炎病毒（HCV）在关节炎病因不明的情况下起着重要作用。乙型和丙型肝炎的临床表现与各种疾病相似，如风湿性疾病。抗环瓜氨酸肽（anti-CCP）是类风湿关节炎的特异性血清学标志物。
本研究旨在分析乙型和丙型肝炎感染患者的抗CCP和类风湿因子（RF）水平。
比较44例乙型肝炎患者、43例丙型肝炎患者、25例类风湿关节炎患者以及46例健康对照者血清中的RF和抗CCP水平。RF采用散射比浊法检测，检测IgM-RF。抗CCP采用酶联免疫吸附测定（ELISA）法检测，该方法包含在第二代抗CCP抗体检测（抗CCP2）中。
HBV组、HCV组、RA组和健康对照组的抗CCP阳性率分别为20.5%、32.5%、72.4%和10.9%。当根据RF阳性率和抗CCP阳性率对各组进行比较时，HBV组、HCV组和健康对照组的值相同，而RA组与其他组有显著差异（p<0.01）。
HBV和HCV感染患者的抗CCP也可能呈阳性，但它是RA诊断的敏感且特异的免疫学标志物，尤其是高滴度时。
