Ma Kefeng, Liu Yi, Xue Zhiqiang, Chu Xiangyang
Department of Thoracic Surgery, The Chinese People's Liberation Army General Hospital Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Beijing, China.
Medicine (Baltimore). 2017 Oct;96(43):e7842. doi: 10.1097/MD.0000000000007842.
Neuroendocrine tumors of the thymus (NETTs) are rare but aggressive, and lead to poor overall survival. This retrospective study was designed to analyze factors that correlate with the prognosis of patients with NETTs.From 1999 to 2015, 41 ongoing patients with NETTs were enrolled in this study. The clinical data and outcome were compiled. Overall survival (OS) rate was analyzed using the Kaplan-Meier method in univariate analysis and the Cox-model was used in multivariate analysis.Of the 41 NETTs patients analyzed (31 male and 10 female), 12 were typical carcinoma, 14 were atypical carcinoma, 14 were small-cell carcinoma and, 1 was large-cell carcinoma. The median follow-up time was 29 months (range, 9.0-69.0). In total, 25 patients died of cancer-related disease by the last follow-up. The 3- and 5-year survival rates for all patients were 42.7% and 23.4%, respectively. Among the prognostic factors analyzed by multivariate analysis, low tumor grade, complete resection, and a negative chromogranin A (CgA) expression were positively correlated with survival.The surgical treatment of NETTs, CgA negative, and low grade of NETTs were associated with a statistically significant better prognosis. However, large, multicenter studies are required to fully validate these prognostic factors.
胸腺神经内分泌肿瘤（NETTs）罕见但具有侵袭性，导致总体生存率较低。本回顾性研究旨在分析与NETTs患者预后相关的因素。1999年至2015年，41例NETTs患者纳入本研究。收集临床数据和结果。单因素分析采用Kaplan-Meier法分析总生存率（OS），多因素分析采用Cox模型。在分析的41例NETTs患者中（31例男性和10例女性），12例为典型癌，14例为非典型癌，14例为小细胞癌，1例为大细胞癌。中位随访时间为29个月（范围9.0 - 69.0）。截至最后一次随访，共有25例患者死于癌症相关疾病。所有患者的3年和5年生存率分别为42.7%和23.4%。多因素分析的预后因素中，低肿瘤分级、完整切除和嗜铬粒蛋白A（CgA）表达阴性与生存呈正相关。NETTs的手术治疗、CgA阴性和低分级NETTs与统计学上显著更好的预后相关。然而，需要大型多中心研究来充分验证这些预后因素。
