Xie Haojun, Li Chufang, Zhang Mincong, Zhong Nanshan, Chen Ling
State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University Academy of Orthopedics of Guangdong Province, Department of Respiratory Disease, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Medicine (Baltimore). 2017 Oct;96(43):e8189. doi: 10.1097/MD.0000000000008189.
The human immunity-related GTPase M (IRGM) is involved in regulating autophagy against invading pathogens. Recently, inconsistent results have been reported about the association between IRGM polymorphisms and tuberculosis risk in several studies.
We searched the PubMed, Embase, and Web of Knowledge, and extracted data from eligible articles to estimate the associations between IRGM polymorphisms (rs10065172, rs4958842, rs4859843, rs4859846, and rs72553867) and tuberculosis risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated using Review manager 5.3. The studies heterogeneity was assessed by Cochran Q test. Funnel plot, Begg test, and Egger linear regression test were used to evaluate the publication bias.
Nine case-control studies in 8 articles involving 3780 tuberculosis and 4835 control were analyzed. The analysis showed that IRGM rs10065172 and rs4859846 were significantly associated with tuberculosis risk in all genetic models whereas the latent tuberculosis infection group in 1 study was excluded. However, stratified analysis revealed significant associations for IRGM rs10065172 in all genetic models among Asians, but not for African/African-Americans. Significant associations were observed in recessive and dominant model for rs4958842, allele and recessive model for rs4859843, and all genetic models for rs4859846. No significant associations between rs72553867 polymorphism and tuberculosis risk was identified. Publication bias was detected in allele and additive model of rs4859843.
IRGM rs10065172 was associated with decreased risk of tuberculosis in Asian populations, but not in African/Africa-Americans. rs4958842, rs4859843, and rs4859846, had a large protective effect in Asians, whereas rs72553867 was not associated with tuberculosis risk.
人类免疫相关鸟苷三磷酸酶M（IRGM）参与调节针对入侵病原体的自噬。最近，几项研究报告了IRGM基因多态性与结核病风险之间关联的不一致结果。
我们检索了PubMed、Embase和Web of Knowledge，并从符合条件的文章中提取数据，以评估IRGM基因多态性（rs10065172、rs4958842、rs4859843、rs4859846和rs72553867）与结核病风险之间的关联。使用Review manager 5.3计算合并比值比（OR）及95%置信区间（CI）。采用Cochran Q检验评估研究的异质性。使用漏斗图、Begg检验和Egger线性回归检验评估发表偏倚。
分析了8篇文章中的9项病例对照研究，共纳入3780例结核病患者和4835例对照。分析表明，在排除1项研究中的潜伏性结核感染组后，IRGM rs10065172和rs4859846在所有遗传模型中均与结核病风险显著相关。然而，分层分析显示，IRGM rs10065172在亚洲人的所有遗传模型中均与结核病风险显著相关，而在非洲人/非裔美国人中则不然。rs4958842在隐性和显性模型中、rs4859843在等位基因和隐性模型中、rs4859846在所有遗传模型中均与结核病风险显著相关。未发现rs72553867基因多态性与结核病风险之间存在显著关联。在rs4859843的等位基因和加性模型中检测到发表偏倚。
IRGM rs10065172与亚洲人群结核病风险降低相关，但与非洲人/非裔美国人无关。rs4958842、rs4859843和rs4859846对亚洲人有较大的保护作用，而rs72553867与结核病风险无关。
