Bonato Fabiana Oliveira Bastos, Canziani Maria Eugênia Fernandes
Universidade Federal de São Paulo.
J Bras Nefrol. 2017 Apr-Jun;39(2):186-195. doi: 10.5935/0101-2800.20170033.
Patients with chronic kidney disease (CKD) are susceptible to the occurrence of ventricular arrhythmias. The leading cause of death in dialysis patients is cardiac arrhythmias. The pathophysiology of arrhythmias in this population is complex and seems to be related to structural cardiac abnormalities caused by CKD, associated with several triggers, such as water and electrolyte disorders, hormonal conditions, arrhythmogenic drugs, and the dialysis procedure itself. Little is known about the clinical outcomes in CKD patients with asymptomatic ventricular arrhythmias. The results of treatments with anti-arrhythmic drugs and invasive devices are controversial in these patients, according to the available literature. The aim of this study was to review this often-neglected topic, which is of special importance in the CKD population.
慢性肾脏病(CKD)患者易发生室性心律失常。透析患者的主要死因是心律失常。该人群心律失常的病理生理学很复杂,似乎与CKD引起的心脏结构异常有关,还与多种触发因素相关,如水和电解质紊乱、激素状况、致心律失常药物以及透析过程本身。对于无症状室性心律失常的CKD患者的临床结局知之甚少。根据现有文献,抗心律失常药物和侵入性器械治疗在这些患者中的效果存在争议。本研究的目的是回顾这个常被忽视的主题,它在CKD人群中具有特殊重要性。