• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

B7-H3促进胃癌细胞的迁移和侵袭。

B7-H3 promotes gastric cancer cell migration and invasion.

作者信息

Li Yecheng, Yang Xiaodong, Wu Yong, Zhao Kui, Ye Zhenyu, Zhu Junjia, Xu Xiaohui, Zhao Xin, Xing Chungen

机构信息

Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, P. R. China.

Department of General Surgery, First Affiliated Hospital of Soochow University, Suzhou, 215006, P.R. China.

出版信息

Oncotarget. 2017 May 13;8(42):71725-71735. doi: 10.18632/oncotarget.17847. eCollection 2017 Sep 22.

DOI:10.18632/oncotarget.17847
PMID:29069741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5641084/
Abstract

B7-H3 (B7 homologue 3, CD276) is a member of the B7 immunoregulatory family and promotes tumor progression. The present study demonstrated that B7-H3 promotes gastric cancer cell migration and invasion. shRNA-mediated B7-H3 silencing in the N87 gastric cancer cell line suppressed cell migration and invasion and ; downregulated metastasis-associated CXCR4; and inhibited AKT, ERK, and Jak2/Stat3 phosphorylation. B7-H3-silenced cells injected into the tail veins of 4-week-old female BALB/c nude mice produced fewer metastases than control cells, and resulted in longer survival times. Immunofluorescence analyses confirmed B7-H3/CXCR4 colocalization in N87 cells, and co-immunoprecipitation assays showed a direct interaction between the two proteins. Our analysis of 120 tissue samples from gastric cancer patients showed that increased B7-H3 expression correlated positively with both tumor infiltration depth and CXCR4 expression. These findings suggest that B7-H3 and CXCR4 may be novel targets for anti-gastric cancer therapeutics.

摘要

B7-H3（B7同源物3，CD276）是B7免疫调节家族的成员，可促进肿瘤进展。本研究表明，B7-H3促进胃癌细胞的迁移和侵袭。在N87胃癌细胞系中，通过短发夹RNA（shRNA）介导的B7-H3沉默可抑制细胞迁移和侵袭；下调与转移相关的CXCR4；并抑制AKT、ERK和Jak2/Stat3磷酸化。将B7-H3沉默的细胞注射到4周龄雌性BALB/c裸鼠的尾静脉中，其产生的转移灶比对照细胞少，且存活时间更长。免疫荧光分析证实N87细胞中B7-H3/CXCR4共定位，免疫共沉淀试验表明这两种蛋白之间存在直接相互作用。我们对120例胃癌患者组织样本的分析表明，B7-H3表达增加与肿瘤浸润深度和CXCR4表达均呈正相关。这些发现表明，B7-H3和CXCR4可能是抗胃癌治疗的新靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/77764b5e8fa2/oncotarget-08-71725-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/127ecd58bfba/oncotarget-08-71725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/098d75f14a55/oncotarget-08-71725-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/e4f9c2ce7684/oncotarget-08-71725-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/129a7a84a363/oncotarget-08-71725-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/77764b5e8fa2/oncotarget-08-71725-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/127ecd58bfba/oncotarget-08-71725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/098d75f14a55/oncotarget-08-71725-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/e4f9c2ce7684/oncotarget-08-71725-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/129a7a84a363/oncotarget-08-71725-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/048a/5641084/77764b5e8fa2/oncotarget-08-71725-g005.jpg

相似文献

1
B7-H3 promotes gastric cancer cell migration and invasion.B7-H3促进胃癌细胞的迁移和侵袭。
Oncotarget. 2017 May 13;8(42):71725-71735. doi: 10.18632/oncotarget.17847. eCollection 2017 Sep 22.
2
B7-H3 silencing inhibits tumor progression of mantle cell lymphoma and enhances chemosensitivity.B7-H3基因沉默抑制套细胞淋巴瘤的肿瘤进展并增强化疗敏感性。
Int J Oncol. 2015;46(6):2562-72. doi: 10.3892/ijo.2015.2962. Epub 2015 Apr 9.
3
B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes.B7-H3 通过调节已知的转移相关基因促进黑色素瘤细胞的转移能力。
Int J Cancer. 2012 May 15;130(10):2282-90. doi: 10.1002/ijc.26238. Epub 2011 Aug 8.
4
Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3.B7-H3的过表达通过Jak2-STAT3增强结肠癌细胞的抗凋亡作用。
World J Gastroenterol. 2015 Feb 14;21(6):1804-13. doi: 10.3748/wjg.v21.i6.1804.
5
B7-H3 Promotes the Migration and Invasion of Human Bladder Cancer Cells via the PI3K/Akt/STAT3 Signaling Pathway.B7-H3通过PI3K/Akt/STAT3信号通路促进人膀胱癌细胞的迁移和侵袭。
J Cancer. 2017 Feb 25;8(5):816-824. doi: 10.7150/jca.17759. eCollection 2017.
6
Aberrant expression of B7-H3 in gastric adenocarcinoma promotes cancer cell metastasis.B7-H3在胃腺癌中的异常表达促进癌细胞转移。
Oncol Rep. 2014 Nov;32(5):2086-92. doi: 10.3892/or.2014.3405. Epub 2014 Aug 14.
7
B7-H3 overexpression in pancreatic cancer promotes tumor progression.B7-H3 在胰腺癌中的过表达促进肿瘤进展。
Int J Mol Med. 2013 Feb;31(2):283-91. doi: 10.3892/ijmm.2012.1212. Epub 2012 Dec 13.
8
B7-H3 increases the radioresistance of gastric cancer cells through regulating baseline levels of cell autophagy.B7-H3通过调节细胞自噬的基线水平增加胃癌细胞的放射抗性。
Am J Transl Res. 2019 Jul 15;11(7):4438-4449. eCollection 2019.
9
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors.B7-H3表达降低会降低糖酵解能力，并使乳腺癌细胞对AKT/mTOR抑制剂敏感。
Oncotarget. 2016 Feb 9;7(6):6891-901. doi: 10.18632/oncotarget.6902.
10
B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway.B7-H3通过JAK2/STAT3信号通路调节涎腺腺样囊性癌的迁移和侵袭。
Am J Transl Res. 2017 Mar 15;9(3):1369-1380. eCollection 2017.

引用本文的文献

1
Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis.胃癌中与迁移体相关的预后基因：转录组学和免疫治疗分析
Onco Targets Ther. 2025 Aug 13;18:873-897. doi: 10.2147/OTT.S528050. eCollection 2025.
2
B7-H3 in Cancer Immunotherapy-Prospects and Challenges: A Review of the Literature.癌症免疫治疗中的B7-H3：前景与挑战——文献综述
Cells. 2025 Aug 6;14(15):1209. doi: 10.3390/cells14151209.
3
Research progress of B7-H3 in malignant tumors.B7-H3在恶性肿瘤中的研究进展

本文引用的文献

1
B7-H3 expression associates with tumor invasion and patient's poor survival in human esophageal cancer.B7-H3表达与人类食管癌的肿瘤侵袭及患者的不良生存相关。
Am J Transl Res. 2015 Dec 15;7(12):2646-60. eCollection 2015.
2
B7-H3 in combination with regulatory T cell is associated with tumor progression in primary human non-small cell lung cancer.B7-H3与调节性T细胞联合作用与原发性人类非小细胞肺癌的肿瘤进展相关。
Int J Clin Exp Pathol. 2015 Nov 1;8(11):13987-95. eCollection 2015.
3
B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.
Front Immunol. 2025 May 30;16:1586759. doi: 10.3389/fimmu.2025.1586759. eCollection 2025.
4
B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature.B7H3在胃肠道肿瘤中的作用：在免疫调节和癌症进展中的作用——文献综述
Cells. 2025 Apr 2;14(7):530. doi: 10.3390/cells14070530.
5
Non-immune functions of B7-H3: bridging tumor cells and the tumor vasculature.B7-H3的非免疫功能：连接肿瘤细胞与肿瘤脉管系统。
Front Oncol. 2024 Jun 17;14:1408051. doi: 10.3389/fonc.2024.1408051. eCollection 2024.
6
B7-H3 Expression in Breast Cancer and Brain Metastasis.B7-H3 在乳腺癌和脑转移中的表达。
Int J Mol Sci. 2024 Apr 3;25(7):3976. doi: 10.3390/ijms25073976.
7
New Emerging Targets in Cancer Immunotherapy: The Role of B7-H3.癌症免疫治疗中的新兴靶点：B7-H3的作用
Vaccines (Basel). 2024 Jan 5;12(1):54. doi: 10.3390/vaccines12010054.
8
Investigational treatment strategies in glioblastoma: progress made and barriers to success.胶质母细胞瘤的研究性治疗策略：取得的进展和成功的障碍。
Expert Opin Investig Drugs. 2023 Jul-Dec;32(10):921-930. doi: 10.1080/13543784.2023.2267982. Epub 2023 Nov 6.
9
B7-H3 Regulates Glucose Metabolism in Neuroblastom via Stat3/c-Met Pathway.B7-H3 通过 Stat3/c-Met 通路调节神经母细胞瘤中的葡萄糖代谢。
Appl Biochem Biotechnol. 2024 Mar;196(3):1386-1398. doi: 10.1007/s12010-023-04606-7. Epub 2023 Jul 5.
10
A Novel Pancreatic Cancer Hypoxia Status Related Gene Signature for Prognosis and Therapeutic Responses.一种新型胰腺癌缺氧状态相关基因特征可用于预后和治疗反应预测。
Mol Biotechnol. 2024 Jul;66(7):1684-1703. doi: 10.1007/s12033-023-00807-x. Epub 2023 Jul 5.
B7-H3通过PI3k-Akt信号通路增加胸苷酸合成酶的表达。
Tumour Biol. 2016 Jul;37(7):9465-72. doi: 10.1007/s13277-015-4740-0. Epub 2016 Jan 20.
4
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors.B7-H3表达降低会降低糖酵解能力，并使乳腺癌细胞对AKT/mTOR抑制剂敏感。
Oncotarget. 2016 Feb 9;7(6):6891-901. doi: 10.18632/oncotarget.6902.
5
Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.RhoA、Rac-1和Cdc42对人食管癌中CXCR4/AKT信号诱导的细胞侵袭和肿瘤转移的调控
Tumour Biol. 2016 May;37(5):6371-8. doi: 10.1007/s13277-015-4504-x. Epub 2015 Dec 2.
6
Interstitial Fluid Flow Increases Hepatocellular Carcinoma Cell Invasion through CXCR4/CXCL12 and MEK/ERK Signaling.间质液流动通过CXCR4/CXCL12和MEK/ERK信号通路增加肝癌细胞侵袭。
PLoS One. 2015 Nov 11;10(11):e0142337. doi: 10.1371/journal.pone.0142337. eCollection 2015.
7
B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway.B7-H3 通过靶向上皮-间充质转化途径中的 JAK2/STAT3/Slug 信号通路促进肝癌的侵袭和转移。
Cancer Cell Int. 2015 Apr 21;15:45. doi: 10.1186/s12935-015-0195-z. eCollection 2015.
8
Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3.B7-H3的过表达通过Jak2-STAT3增强结肠癌细胞的抗凋亡作用。
World J Gastroenterol. 2015 Feb 14;21(6):1804-13. doi: 10.3748/wjg.v21.i6.1804.
9
Expression of SNCG, MAP2, SDF-1 and CXCR4 in gastric adenocarcinoma and their clinical significance.SNCG、MAP2、SDF-1及CXCR4在胃腺癌中的表达及其临床意义。
Int J Clin Exp Pathol. 2014 Sep 15;7(10):6606-15. eCollection 2014.
10
Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer.STAT3的激活参与了人乳腺癌中由CXCL12-CXCR4信号介导的恶性肿瘤形成过程。
Oncol Rep. 2014 Dec;32(6):2760-8. doi: 10.3892/or.2014.3536. Epub 2014 Oct 10.