老年血液系统恶性肿瘤患者的心理困扰、慢性疾病和生活质量：一项前瞻性研究的研究方案。

Psychological distress, chronic conditions and quality of life in elderly hematologic cancer patients: study protocol of a prospective study.

机构信息

Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Philipp-Rosenthal-Strasse 55, 04103, Leipzig, Germany.

出版信息

BMC Cancer. 2017 Oct 25;17(1):700. doi: 10.1186/s12885-017-3662-1.

DOI:10.1186/s12885-017-3662-1

PMID:29070033

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5655829/

Abstract

BACKGROUND

Similar to most solid tumors, the incidence of hematologic malignancies has been rising. Although the median age at diagnosis is about 70 years, little is known about psychosocial aspects and comorbid conditions in elderly patients with hematologic cancers. The main objectives of our study are to assess the prevalence of psychological distress, chronic conditions, functional disabilities, and quality of life in both elderly hematologic cancer patients aged ≥70 years and an age-matched comparison sample of the general population.

METHODS

We conduct a prospective study with three measuring points (t_1: ≥5 years after first time hematologic cancer diagnosis / relapse; t_2 and t_3 six months and 1 year after t_1). In addition, we use a cross sectional study design to recruit a comparison sample of the general population matched by age and sex. Both samples, patients and the comparison group complete validated questionnaires measuring psychological distress, chronic conditions, functional disabilities, and quality of life as well as health care needs and health care utilization.

DISCUSSION

Our study will provide both a data set offering detailed information about elderly hematologic cancer patients' physical, psychological and demographic characteristics, and reference data of the elderly general population. Furthermore, the study will provide important information for the development and implementation of psychooncological support offers and survivorship care plans.

摘要

背景

与大多数实体瘤类似，血液系统恶性肿瘤的发病率一直在上升。尽管诊断时的中位年龄约为 70 岁，但对于老年血液系统恶性肿瘤患者的心理社会方面和合并症知之甚少。我们研究的主要目的是评估≥70 岁老年血液系统恶性肿瘤患者和年龄匹配的一般人群对照样本中心理困扰、慢性疾病、功能障碍和生活质量的患病率。

方法

我们进行了一项前瞻性研究，有三个测量时间点（t_1：首次血液系统恶性肿瘤诊断/复发后≥5 年；t_2 和 t_3 在 t_1 后 6 个月和 1 年）。此外，我们采用横断面研究设计招募年龄和性别匹配的一般人群对照样本。患者和对照组样本均完成了经过验证的问卷，以测量心理困扰、慢性疾病、功能障碍和生活质量以及医疗保健需求和利用情况。