在苏格兰分离出的革兰氏阴性菌中的头孢菌素耐药性。

Cephaloridine resistance in gram-negative bacteria isolated in Scotland.

作者信息

Reid A J, Simpson I N, Harper P B, Amyes S G

机构信息

Department of Bacteriology, Medical School, University of Edinburgh, UK.

出版信息

J Pharm Pharmacol. 1988 Aug;40(8):571-3. doi: 10.1111/j.2042-7158.1988.tb05306.x.

DOI:10.1111/j.2042-7158.1988.tb05306.x

PMID:2907014

Abstract

The incidence of cephaloridine resistance (minimum inhibitory concentration, MIC greater than 8 mg L-1) in isolates from urinary tract infections was 45.1% in Glasgow, 22.6% in Dundee and 25.9% in Edinburgh. The incidence of ampicillin resistance (MIC greater than 8 mg L-1) was even higher:- being 45.2% in Dundee and 48.5% in Edinburgh. In Glasgow, the incidence was 71.9% which is the highest proportion of ampicillin resistance reported in the United Kingdom. The cephaloridine resistant strains were examined for beta-lactamase production. Amongst these strains 50.8% produced only a chromosomal beta-lactamase, whereas 47.9% produced beta-lactamases which were potentially plasmid-mediated on the basis of biochemical tests. Only 1% of the resistant strains produced no detectable beta-lactamase.

摘要

在格拉斯哥，尿路感染分离株中头孢菌素耐药（最低抑菌浓度，MIC大于8mg/L）的发生率为45.1%，在邓迪为22.6%，在爱丁堡为25.9%。氨苄西林耐药（MIC大于8mg/L）的发生率更高：在邓迪为45.2%，在爱丁堡为48.5%。在格拉斯哥，发生率为71.9%，这是英国报道的氨苄西林耐药的最高比例。对头孢菌素耐药菌株进行了β-内酰胺酶产生情况检测。在这些菌株中，50.8%仅产生染色体β-内酰胺酶，而根据生化试验，47.9%产生的β-内酰胺酶可能由质粒介导。只有1%的耐药菌株未检测到β-内酰胺酶。