新生和成年大鼠中多巴胺受体对皮质酮分泌的调节

Dopamine receptor modulation of corticosterone secretion in neonatal and adult rats.

作者信息

Kitchen I, Kelly M, Turner M

机构信息

Department of Biochemistry, University of Surrey, Guildford, UK.

出版信息

J Pharm Pharmacol. 1988 Aug;40(8):580-1. doi: 10.1111/j.2042-7158.1988.tb05309.x.

DOI:10.1111/j.2042-7158.1988.tb05309.x

PMID:2907016

Abstract

The effects of the dopamine agonist, pergolide, upon plasma corticosterone levels have been studied in 30 day old neonatal and adult rats. Dose-related elevations in corticosterone were observed at both ages and these elevations were blocked by the dopamine (D2) receptor antagonist spiperone. These studies demonstrate that dopaminergic neurochemical control of the hypothalamus-pituitary-adrenal axis exists in four week old rats in contrast to our previous studies which have shown opioid control to be absent at this age. It appears that neurochemical control of corticosterone is dissimilar in the neonate.

摘要

已在30日龄的新生大鼠和成年大鼠中研究了多巴胺激动剂培高利特对血浆皮质酮水平的影响。在两个年龄段均观察到皮质酮呈剂量相关的升高，并且这些升高被多巴胺（D2）受体拮抗剂螺哌隆阻断。这些研究表明，与我们之前显示该年龄不存在阿片类物质控制的研究相反，四周龄大鼠存在下丘脑 - 垂体 - 肾上腺轴的多巴胺能神经化学控制。新生儿皮质酮的神经化学控制似乎有所不同。