头孢菌素类抗生素的肠道吸收：肠道吸收与刷状缘膜转运之间的相关性
Intestinal absorption of cephalosporin antibiotics: correlation between intestinal absorption and brush-border membrane transport.
作者信息
Hori R, Okano T, Kato M, Maegawa H, Inui K
机构信息
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.
出版信息
J Pharm Pharmacol. 1988 Sep;40(9):646-7. doi: 10.1111/j.2042-7158.1988.tb05327.x.
The absorption of seven cephalosporin antibiotics from the in-situ intestinal loop at pH 7.4 and their transport by brush-border membrane vesicles in the presence of an inward H+ gradient ([pH]i = 7.5, [pH]o = 6.0) were examined. A good correlation was found between the intestinal absorption rate and the initial uptake rate by brush-border membrane vesicles. The data suggest that the transport study using intestinal brush-border membrane vesicles is useful as a model system for the intestinal absorption of beta-lactam antibiotics.
研究了7种头孢菌素抗生素在pH 7.4时从原位肠袢的吸收情况，以及在存在内向H⁺梯度（[pH]i = 7.5，[pH]o = 6.0）的情况下它们通过刷状缘膜囊泡的转运情况。发现肠吸收速率与刷状缘膜囊泡的初始摄取速率之间存在良好的相关性。数据表明，使用肠刷状缘膜囊泡进行的转运研究作为β-内酰胺抗生素肠吸收的模型系统是有用的。
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