巨噬细胞移动抑制因子-1对α-促黑素细胞激素诱导的兔眼内压升高和瞳孔缩小的抑制作用。

Inhibition by MIF-I of alpha-MSH induced increase of intraocular pressure and miosis in rabbits.

作者信息

McCullen R K, Peiffer R L, Jennes L, Hernandez D E

机构信息

Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill 27514.

出版信息

Neuropeptides. 1988 Nov-Dec;12(4):213-7. doi: 10.1016/0143-4179(88)90057-1.

DOI:10.1016/0143-4179(88)90057-1

PMID:2907121

Abstract

The effects of intracameral (i.c.) administration of MIF-I on the ocular response to alpha-MSH were tested in rabbits. In confirmation of previous studies, i.c. alpha-MSH significantly increased intraocular pressure (IOP) and reduced pupillary diameter (PD). Concomitant administration of alpha-MSH and MIF-I antagonized both the IOP increase and miosis induced by alpha-MSH. Aqueous humor (AH) dynamics studies revealed that alpha-MSH increases IOP, possibly, by decreasing AH outflow. The decreased AH outflow induced by alpha-MSH was antagonized by concurrent administration of MIF-I and alpha-MSH. MIF-I did not affect IOP or PD when administered alone. These results add more support for a role of alpha-MSH in ocular function, and suggest that the ocular response to alpha-MSH may be subject to inhibitory control by MIF-I.

摘要

在兔子身上测试了前房内注射巨噬细胞移动抑制因子-1（MIF-1）对眼睛对α-促黑素（α-MSH）反应的影响。正如之前研究所证实的，前房内注射α-MSH可显著升高眼压（IOP）并减小瞳孔直径（PD）。同时给予α-MSH和MIF-1可拮抗α-MSH引起的眼压升高和瞳孔缩小。房水（AH）动力学研究表明，α-MSH可能通过减少房水流出而升高眼压。同时给予MIF-1和α-MSH可拮抗α-MSH引起的房水流出减少。单独注射MIF-1时对眼压或瞳孔直径没有影响。这些结果进一步支持了α-MSH在眼功能中的作用，并表明眼睛对α-MSH的反应可能受到MIF-1的抑制控制。